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Lawesson's reagent

Lawesson's reagent structure

CAS No:
19172-47-5
Formula:
C14H14O2P2S4
Chemical Name:
Lawesson's reagent
Synonyms:
1,3,2,4-Dithiadiphosphetane,2,4-bis(4-methoxyphenyl)-,2,4-disulfide;Phosphonotrithioic acid,(p-methoxyphenyl)-,bimol. cyclic anhydrosulfide;p-Anisyldithiophosphonic anhydride;2,4-Bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide;Lawesson's reagent;2,4-Bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide;Reagents,Lawesson's;2,4-Di(p-methoxyphenyl)-1,3-dithiadiphosphetane disulfide;NSC 150550;2,4-Bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane;2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide;Lawesson reagent;2,4-(4-Methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide;114668-60-9;136390-48-2;72728-81-5;94367-93-8
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

light yellow to beige powderLawesson's reagent, also known as Lloyd's reagent, is a commonly used chemical reagent in the preparation of organic sulfur compounds. At room temperature under normal pressure, it appears as the solid yellow powder with a strong smell of rotten. In 1956, it was first successfully produced by the reaction between arene and tetraphosphorus decasulfide. The Swedish chemist Sven-Olov Lawesson has carefully studied its reaction with organic compounds, so that its applica

Lawesson's reagent Basic Attributes

Molecular Weight：

404.47

Exact Mass：

404.47

BRN：

1024888

EC Number：

242-855-4

UNII：

A4125MQ8RX

NSC Number：

150550

DSSTox ID：

DTXSID4066460

HScode：

29349990

Characteristics

PSA：

152.86000

XLogP3：

6.05480

Appearance：

White to almost white Powder

Density：

1.48±0.1 g/cm3(Predicted)

Melting Point：

229 °C

Boiling Point：

525.8±60.0 °C(Predicted)

Flash Point：

271.8±32.9 °C

Refractive Index：

1.706

Water Solubility：

Decomposition

Storage Conditions：

water-free area

Vapor Pressure：

1.28E-10mmHg at 25°C

Safety Information

Packing level：

III

Hazard category：

4.3

Transport codes：

3278

wgk germany：

hazard class code：

20/21/22-15/29-37

safety instructions：

8-43-36/37-22-38-7/8

Marks：

Xn-F,Xi,Xn,F

Precautionary statement(s)：

P231 + P232-P422

Hazard Statements：

H261

GHS Classification：

|Warning|H261 (85.45%): In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]|P231+P232, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P370+P378, P402+P404, and P501|Aggregated GHS information provided by 55 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide

Lawesson's reagent Use and Manufacturing

Uses

Thiation reagent.

Manufacturing Info：

1,3,2,4-Dithiadiphosphetane, 2,4-bis(4-methoxyphenyl)-, 2,4-disulfide: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:404.5
XLogP3:6.1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:403.93518837
Monoisotopic Mass:403.93518837
Topological Polar Surface Area:133
Heavy Atom Count:22
Complexity:425
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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