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Fosfomycin sodium

Fosfomycin sodium structure

CAS No:
26016-99-9
Formula:
C3H7O4P.2Na
Chemical Name:
Fosfomycin sodium
Synonyms:
Phosphonic acid,P-[(2R,3S)-3-methyl-2-oxiranyl]-,sodium salt (1:2);Phosphonic acid,(1,2-epoxypropyl)-,disodium salt,(1R,2S)-(-)-;Phosphonic acid,(3-methyloxiranyl)-,disodium salt,(2R-cis)-;Phosphonic acid,[(2R,3S)-3-methyloxiranyl]-,disodium salt;Disodium phosphonomycin;Disodium fosfomycin;Fosfomycin disodium;Phosphonomycin disodium salt;Fosfomycin sodium salt;Fosfomycin sodium;Fosfomycin disodium salt;Phosphonomycin sodium;Sodium fosfomycin;Phosphomycin sodium;Fosmicin S;Fosfocin;FOM-Na;Forocyle S;NSC 136017;Levo-phosphonomycin disodium salt;25030-61-9
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Fosfomycin sodium (MK-0955 sodium) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].

Fosfomycin sodium Basic Attributes

Molecular Weight：

182.023

Exact Mass：

181.972092

EC Number：

247-409-2

UNII：

97MMO19FNO

HScode：

29419090

Characteristics

PSA：

85.53000

XLogP3：

0.78530

Appearance：

White Solid

Melting Point：

>300°C

Boiling Point：

342.7ºC at 760 mmHg

Flash Point：

161ºC

Water Solubility：

Freely soluble in water or aqueous solution

Storage Conditions：

2-8ºC

Vapor Pressure：

1.34E-05mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R11

safety instructions：

16-26-36/37/39-45

RTECS Number：

SZ7902000

Marks：

F: Flammable;C: Corrosive;

GHS Classification：

|Danger|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P260, P261, P263, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P308+P313, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 5 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fosfomycin sodium Use and Manufacturing

Uses

For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella. Curariform muscle relaxants Disodium phosphonomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine

Use Classification：

Human drugs -> Rare disease (orphan)

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fosfomycin sodium

Fosfomycin Sodium for Injection
Ingredients	The main ingredients of this product are: Fosfomycin sodium
Specifications	Calculated as C3H7O4P 2.0g (2 million units)
Manufacturer	Harbin Pharmaceutical Group Co., Ltd. GENERAL Pharm. FACTORY

Fosfomycin sodium
Manufacturer	NORTHEAST Pharmaceutical Group Co., Ltd.

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Registered Holders

MSN ORGANICS PRIVATE LTD

United States
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active
Shanxi Dongjin Pharmaceutical Co., Ltd.

China
Active

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