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Disodium phosphonomycin

Disodium phosphonomycin structure

CAS No:
26016-99-9
Formula:
C3H8NaO4P
Chemical Name:
Disodium phosphonomycin
Synonyms:
[(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid disodium salt;disodium [(2R,3S)-3-methyloxiran-2-yl]-bis(oxidanidyl)-oxo-$l^{5}-phosphane;disodium [(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-$l^{5}-phosphane;disodium keto-[(2R,3S)-3-methyloxiran-2-yl]-dioxido-phosphorane;Sodium ((2S,3R)-3-methyloxiran-2-yl)phosphonate;2S)-1;(1,2-epoxypropyl)-,disodiumsalt(1r,2s)(-)-phosphonicaci;(2r-cis)-(3-methyloxiranyl)phosphonicaciddisodiumsalt
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Fosfomycin sodium (MK-0955 sodium) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].

White Solid

Disodium phosphonomycin Basic Attributes

Molecular Weight：

162.06

Exact Mass：

181.972092

BRN：

4604425

EC Number：

247-409-2

UNII：

97MMO19FNO

Color/Form：

White to Off-White

HScode：

29419090

Characteristics

PSA：

85.53000

XLogP3：

0.78530

Appearance：

White Solid

Melting Point：

>300°C

Boiling Point：

342.7ºC at 760 mmHg

Flash Point：

161ºC

Water Solubility：

Freely soluble in water or aqueous solution

Storage Conditions：

2-8ºC

Vapor Pressure：

1.34E-05mmHg at 25°C

Critical Temperature & Pressure：

Inert atmosphere,2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

F,C

safety instructions：

16-26-36/37/39-45

RTECS Number：

SZ7902000

Marks：

F: Flammable;C: Corrosive;

Hazard Statements：

11-34

GHS Classification：

|Danger|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P260, P261, P263, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P308+P313, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 5 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Disodium phosphonomycin Use and Manufacturing

Uses

For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella. Curariform muscle relaxants Disodium phosphonomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine

For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella.

Curariform muscle relaxants

Prevents peptidoglycan synthesis by inhibiting MurA, an enzyme responsible for synthesizing N-acetylmuramic acid or NAM, a major component of peptidoglycan

Use Classification：

Human drugs -> Rare disease (orphan)

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fosfomycin sodium

Fosfomycin Sodium for Injection
Ingredients	The main ingredients of this product are: Fosfomycin sodium
Specifications	Calculated as C3H7O4P 2.0g (2 million units)
Manufacturer	Harbin Pharmaceutical Group Co., Ltd. GENERAL Pharm. FACTORY

Fosfomycin sodium
Manufacturer	NORTHEAST Pharmaceutical Group Co., Ltd.

See More Related Drugs

Registered Holders

MSN ORGANICS PRIVATE LTD

United States
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active
Shanxi Dongjin Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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