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Bromhexine hydrochloride

Bromhexine hydrochloride structure

CAS No:
611-75-6
Formula:
C14H21Br2ClN2
Chemical Name:
Bromhexine hydrochloride
Synonyms:
2-AMINO-3,5-DIBROMO-N-CYCLOHEXYL-N-METHYLBENZY-LAMINE HYDROCHLORIDE;n-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine hydrochloride;2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-benzenemethanaminmonohydrochlo;2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylaminehydrochloride;2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-benzylaminhydrochloride;bisolvon;bisolvonhydrochloride;bromessina
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

White Solid

Bromhexine Hydrochloride is the hydrochloride salt form of bromhexine, a secretolytic, with mucolytic activity. Upon administration, bromhexine increases lysosomal activity and enhances hydrolysis of acid mucopolysaccharide polymers in the respiratory tract. This increases the production of serous mucus in the respiratory tract, which makes the phlegm thinner and decreases mucus viscosity. This contributes to its secretomotoric effect, and allows the cilia to more easily transport the phlegm out of the lungs. This clears mucus from the respiratory tract and may aid in the treatment of respiratory disorders associated with abnormal viscid mucus, excessive mucus secretion and impaired mucus transport.

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of spu um).

Bromhexine hydrochloride is a bronchial mucolytic.

Bromhexine hydrochloride Basic Attributes

Molecular Weight：

412.59

Exact Mass：

411.974

BRN：

4848376

EC Number：

210-280-8

Color/Form：

White to Light Beige

HScode：

29215990

Characteristics

λmax：

307nm(Decane)(lit.)

PSA：

29.3

XLogP3：

5.94150

Appearance：

White Solid

Melting Point：

240-244 °C

Boiling Point：

441.5ºC at 760 mmHg

Flash Point：

220.8ºC

Storage Conditions：

2-8ºC

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

wgk germany：

hazard class code：

safety instructions：

22-24/25-36-26

RTECS Number：

XS9950000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P391, P403+P233, P405, P501

Hazard Statements：

20/21/22-36/37/38

Bromhexine hydrochloride Use and Manufacturing

antibacterial Expectorant; mucolytic. Antimucolytic

Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity.

Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.Bromhexine hydrochloride belongs to the group of expectorants (mucoactive agents). The active substance has a secretolytic effect. It is used for the treatment of strong cough, e.g. triggered by a bronchitis.

Material

o-Toluidine

Drug Function and Efficacy

Expectorants can reduce the viscosity of bronchial mucus, making sputum thinner and easier to cough up

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Chlorprenaline Houttuynia Sodium Tablets
Ingredients	Each tablet contains 4 mg of chlorprenaline hydrochloride, 4 mg of bromhexine hydrochloride, 20 mg of houttuynia cordata sodium, and 1.5 mg of chlorpheniramine maleate. The auxiliary materials are appropriate amounts of starch and dextrin.
Indication	1. Do not use with monoamine oxidase inhibitors (such as furazolidone, pargyline, etc.). 2. Do not use with other bronchodilator beta-2 receptor agonists. 3. Use with anticholinergics or theophylline drugs to enhance the effect of relieving asthma. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	Compound
Manufacturer	Jilin Xianfeng Technical Pharmaceutical Co., Ltd.

Tulobuterol Hydrochloride Tablets
Ingredients	Tulobuterol hydrochloride, bromhexamine hydrochloride, promethazine hydrochloride, and appropriate amount of excipients.
Indication	It is well absorbed orally and the effective concentration in the blood can be maintained for 6 hours.
Specifications	0.5mg
Manufacturer	Xi`an Han Feng Pharmaceutical Co., Ltd.

Compound chlorprenaline and bromhexine tablets
Ingredients	Chlorprenaline hydrochloride 5mg, bromhexine hydrochloride 10mg, deschlorohydroxyzine hydrochloride 25mg
Indication	1. It has an additive effect when used in combination with other bronchial β2 receptor agonists. 2. When this product is used in combination with other β2 receptor agonists, the efficacy is reduced and adverse reactions such as hand tremors and palpitations may be more obvious. 3. If used in combination with phosphodiesterase inhibitors such as theophylline or anticholinergic antiasthmatic drugs, its bronchial dilation and asthma relief effects are enhanced. 4. Bromhexine hydrochloride can increase the concentration of tetracycline antibiotics in the bronchi.
Specifications	Chlorprenaline hydrochloride 5mg, bromhexine hydrochloride 10mg, deschlorohydroxyzine hydrochloride 25mg
Manufacturer	Zhejiang Dongri Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

FDC LIMITED

United Kingdom
Active
株式会社三洋化学研究所

Japan
Active
China CHINO PHARMA Ltd

China
Active

See More Registered Holders

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