 Home > Encyclopedia > Niraparib tosylate

Niraparib tosylate

Niraparib tosylate structure

CAS No:
1613220-15-7
Formula:
C26H30N4O5S
Chemical Name:
Niraparib tosylate
Synonyms:
MK-4827, Niraparib TsOH salt hydrate
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Niraparib Tosylate Monohydrate is an orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.

Niraparib tosylate Basic Attributes

Molecular Weight：

510.6052

Exact Mass：

510.193695

UNII：

195Q483UZD

NCI Thesaurus Code：

C133238

Characteristics

PSA：

135.69

XLogP3：

5.943

Safety Information

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P312, P308+P313, P314, P330, P391, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Computed Properties

Molecular Weight:510.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:510.19369124
Monoisotopic Mass:510.19369124
Topological Polar Surface Area:137
Heavy Atom Count:36
Complexity:655
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Recommended Suppliers of Niraparib tosylate

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Niraparib Tosylate Monohydrate cas 1613220-15-7

CAS No.: 1613220-15-7

Grade: Analytical Reagent

Content: 99%

Inquiry
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of Peptides,API,Intermediate

Niraparib tosylate

CAS No.: 1613220-15-7

Grade: medical grade

Content: 98%

Inquiry