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Croscarmellose sodium

Croscarmellose sodium structure

CAS No:
74811-65-7
Chemical Name:
Croscarmellose sodium
Synonyms:
Croscarmellose sodium;AcDiSol;Sodium croscarmellose;Primellose;Explocel;Nymcel ZSX;Pharmacel XL;Vivasol;Kiccolate;Kiccolate ND 2HS;Kiccolate ND 200;Croscarmellose;Ac-Di-Sol SD 711;Cross carboxymethyl cellulose sodium;ND 2HS;Ac-Di-Sol SD 411NF;Ac-Di-Sol SDW 802NF;Kiccolate NDHS;Ac-Di-Sol SDW 802;357172-57-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

pH 5.0-7.0 tablet disintegrant. Croscarmellose sodium occurs as an odorless, white or grayishwhite powder.

Croscarmellose sodium Basic Attributes

Molecular Weight：

263.2 g/mol

Exact Mass：

263.074287 g/mol

EC Number：

618-326-2

Characteristics

PSA：

156 Å²

Appearance：

OtherSolid

Density：

Bulk density (g/cc) 0.48

Water Solubility：

Yields a viscous colloidal solution with water. Insoluble in ethanol

Storage Conditions：

Croscarmellose sodium is a stable though hygroscopic material.
A model tablet formulation prepared by direct compression, withcroscarmellosesodiumasadisintegrant,showednosignificant differenceindrugdissolutionafterstorageat30°Cfor14months.
Croscarmellose sodium should be stored in a well-closed container in a cool, dry place.

PH：

Not less than 5,0 and not more than 8,5 (1 % colloidal solution)

Croscarmellose sodium Use and Manufacturing

Packaged under nitrogen antimicrobial Used as Disintegrant in Capsules, Tablet and Granule Formulations. Pharmaceutic aid (tablet disintegrant).

Drug Function and Efficacy

This product acts directly on the gastrointestinal wall, increasing gastrointestinal motility and tension, promoting gastric emptying, increasing gastric antrum and duodenal motility, coordinating pyloric contraction, and also enhancing esophageal motility and the tension of the lower esophageal sphincter, inhibiting nausea and vomiting. This product is not easy to pass through the blood-brain barrier.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Domperidone orally disintegrating tablets
Ingredients	Each tablet of this product contains 10 mg of domperidone. The excipients are microcrystalline cellulose, cross-linked sodium carboxymethyl cellulose, aspartame, and micro-powdered silica. Chemical name: 5-chloro-1[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidinyl]-2-benzimidazolinone Molecular weight: C22H24ClN5O2
Indication	1. It should not be used together with azole antifungal drugs such as ketoconazole and itraconazole, macrolide antibiotics such as erythromycin, HIV protease inhibitors and nefazodone. 2. Anticholinergic drugs such as tamoxifen, propantheline bromide, anisodamine, belladonna tablets, etc. will weaken the effect of this product and should not be taken with this product. 3. Antacids and drugs that inhibit gastric acid secretion can reduce the bioavailability of this product and should not be taken with this product. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	10mg

Domperidone orally disintegrating tablets
Ingredients	Each tablet of this product contains 10 mg of domperidone. The excipients are microcrystalline cellulose, cross-linked sodium carboxymethyl cellulose, aspartame, and micro-powdered silica gel.
Indication	1. It should not be used together with azole antifungal drugs such as ketoconazole and itraconazole, macrolide antibiotics such as erythromycin, HIV protease inhibitors and anti-AIDS drugs and nefazodone. 2. Anticholinergic drugs such as tacrolimus, propantheline bromide, scopolamine, belladonna tablets, etc. will weaken the effect of this product and should not be taken together with this product. 3. Antacids and drugs that inhibit gastric acid secretion can reduce the bioavailability of this product and should not be taken together with this product. 4. When this product is used together with acetaminophen, ampicillin, levodopa, tetracycline, etc., the absorption rate of these drugs will increase. 5. When this product is used in combination with digoxin, the absorption of the latter will be reduced. 6. Domperidone does not enhance the effect of neuroleptics; this product should not be used simultaneously with monoamine oxidase inhibitors (MAOIs). 7. Because domperidone has
Specifications	10mg
Manufacturer	North China Pharmaceutical Company.Ltd

Acetaminophen orally disintegrating tablets
Ingredients	Each tablet of this product contains 160 mg of acetaminophen as the main ingredient. The auxiliary materials are: glycine, lactose, microcrystalline cellulose, aspartame, citric acid, cross-linked sodium carboxymethyl cellulose, talc, polyvidone (PVP), edible flavors and edible coloring.
Indication	1. Long-term use of this product by patients who use barbiturates (phenobarbital) or antispasmodics (such as belladonna) may cause liver damage. 2. This product can enhance the toxicity of chloramphenicol when used together with aspirin or other non-steroidal anti-inflammatory drugs for a long time. There is a significant risk of increased nephrotoxicity. 4. When this product is used together with the antiviral drug Zidovudine, its toxicity can be increased and should be avoided at the same time. 5. If you are taking other medicines, please consult a doctor or pharmacist before using this product.
Specifications	0.16g
Manufacturer	Ningbo Liwah Pharmaceutical Co., Ltd.

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Registered Holders

Luogaite Health Pharmaceuticals (Shanghai) Co., Ltd.

China
Active
MAPLE BIOTECH PVT LTD

India
Active
Zhongnuo Kailin Pharmaceutical Development (Suzhou) Co., Ltd.

China
Active

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