Z-360
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Z-360
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CAS No:
209219-38-5
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Formula:
C29H36N4O5
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Chemical Name:
Z-360
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Synonyms:
Nastorazepide;Nastorazepide (Z-360);3-[[[[(3R)-5-Cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2,3,4,5-tetrahydro-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]benzoic acid;Nastorazepide Calcium
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CAS No:
Description
Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target：CCK-2in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo:
Computed Properties
Molecular Weight:520.6
XLogP3:4.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:520.26857026
Monoisotopic Mass:520.26857026
Topological Polar Surface Area:119
Heavy Atom Count:38
Complexity:881
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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