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Fluralaner

Fluralaner structure

CAS No:
864731-61-3
Formula:
C22H17Cl2F6N3O3
Chemical Name:
Fluralaner
Synonyms:
Fluralaner;A1443; AH252723;AH252723;Fluralaner-012;Fluralaner (A1443;Frellana;Fluralaner D2Q: What is Fluralaner D2 Q: What is the CAS Number of Fluralaner D2;Fluralaner D3Q: What is Fluralaner D3 Q: What is the CAS Number of Fluralaner D3
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

Fluralaner Basic Attributes

Molecular Weight：

556.29

Exact Mass：

556.29

EC Number：

200-001-8

DSSTox ID：

DTXSID90235581

Color/Form：

White to off-white

ATC Code：

QP53BE02|QP54AB52

Characteristics

Density：

1.51±0.1 g/cm3(Predicted)

PKA：

12.50±0.46(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Safety Information

GHS Classification：

|Warning|H361 (19.17%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P273, P281, P308+P313, P391, P405, and P501|Aggregated GHS information provided by 193 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Dogs:- For the treatment of tick and flea infestations;The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).- For the treatment of demodicosis caused by Demodex canis;- For the treatment of sarcoptic mange (Sarcoptes scabiei var. canis) infestation.Cats:- For the treatment of tick and flea infestations;The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).- For the treatment of infestations with ear mites (Otodectes cynotis).|For cats with, or at risk from, mixed parasitic infestations by ticks or fleas and ear mites, gastrointestinal nematodes or heartworm. The veterinary medicinal product is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time.For the treatment of tick and flea infestations in cats providing immediate and persistent flea (Ctenocephalides felis) and tick (Ixodes ricinus) killing activity for 12 weeks. Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).For the treatment of infestations with ear mites (Otodectes cynotis).For the treatment of infections with intestinal roundworm (4th stage larvae, immature adults and adults of Toxocara cati) and hookworm (4th stage larvae, immature adults and adults of Ancylostoma tubaeforme).When administered repeatedly at a 12-week interval, the product continuously prevents heartworm disease caused by Dirofilaria immitis|Treatment of poultry red mite (Dermanyssus gallinae) infestation in pullets, breeders and layer hens.,

MeSH Entry Terms：

A1443 compound

Fluralaner Use and Manufacturing

Uses

Fluralaner(864731-61-3) is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.

Use Classification：

Veterinary drugs -> Bravecto -> EMA Drug Category|Ectoparasiticides for systemic use, Isoxazolines -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Bravecto Plus -> EMA Drug Category|Antiparasitic products, insecticides and repellents, Endectocides, Milbemycins -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Exzolt -> EMA Drug Category|Ectoparaciticides, insecticides and repellents -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

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