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Monostearin

Monostearin structure

CAS No:
31566-31-1
Formula:
C21H42O4
Chemical Name:
Monostearin
Synonyms:
Octadecanoic acid,monoester with 1,2,3-propanetriol;Stearin,mono-;Monoglyceryl stearate;Glycerol monostearate;Monostearin;Kao Atorum P 40S;Glyceryl monostearate;Glycerin monostearate;Imwitor 191;Nikkol MGS-A;Sinnoester SG;Vykamol S/E;Vykamol N/E;Advawax 140;Myvaplex;Hallmark GMS;Stearic acid glycerol monoester;Rikemal S 100;Nikkol MGS;Imwitor 960K;GMS (glyceride);Stearic acid monoglyceride;Glycerol monooctadecanoate;GMS 90;Aldo SMV;Imwitor 900K;Monogly MB;Aldo MS;Cerasynt SD;Electrostripper TS 5;GMS;Polynol A;Rikemal RMS 100;Aldo 28;Empilan GMS-SE 40;Loxiol G 12;R 60 (glyceride);R 60;Empilan GMS/NSE 40;Cithrol GMS;Rikemal S 100A;KPL 1;Cutina GMS;Rewomul MG;Hostalub FE 2;Atmer 129;CPH 53N;Nissan Monogly MB;Nissan Monogly;Nikkol MGS-ASE;Cerasynt 945;S 100A;Capmul GMS 40;Drewmulse GMS-AE;Brian M 1;Stearic monoglyceride;Poem S 100V;Dimodan PM;Dur-Em 117;Myvaplex 600;Rheodol MS 50;Excel 124;Cerasynt Q;Sunsoft 8000;Rikemal 100;Glycolube 825;Estol 1463;Lipo GMS 470;Rheodol MS 60;TB 123;Denon 2068;Atmer 128;Pelemol GS;Myvaplex 600P;Imwitor 960;Anstex MG 100;Loxiol EP 12;Rikemal 100A;MB 400;S 100;Glycerine monostearate;Cerasynt GMS;Atmer 126;Monogly D;Alkamuls GMS-C;MGS-B;Pationic 902;Pationic 901;Edenor GMS;Nikkol MGS-F 20;Citomulgan T00-785;Citomulgan TOO-785;Myverol 18-06K;Emalsy MH;Radiasurf 7140/3;Sorbon MG 100;Kessco GMS Pure;TS 5;Nissan Monogly 5;Monogly 5;Nikkol MGS-F 50;TG-C;1319-95-5;8029-22-9;8039-58-5;8045-31-6;8050-92-8;12676-39-0;37297-05-5;55962-68-0;58615-57-9;61163-94-8;64366-44-5;69073-02-5;86904-15-6;87714-32-7;100041-47-2;109767-98-8;110618-11-6;119758-60-0;146586-29-0;150605-03-1;176365-67-6;177645-80-6;200138-94-9;209533-94-8;413576-89-3;696587-54-9;902145-16-8;1361318-46-8;1617532-55-4;2025308-77-2
Categories:
Cosmetic Ingredient > Emulsifying Agent

Description

ChEBI: A rac-1-monoacylglycerol composed of equal amounts of 3-stearoyl-sn-glycerol and 1-stearoyl-sn-glycerol.Monostearin (also known as 1-Stearoyl-rac-glycerol) is a long chain molecule typically occurring in the body as a by-product of the breakdown of fats. It is one of the panels of serum metabolic biomarkers for detecting and diagnosing cancer, especial ovarian cancer. It is also used in the development of drug delivery vehicles such as nanoparticles and microemulsions. It can also be

Monostearin Basic Attributes

Molecular Weight：

358.556

Exact Mass：

358.308

EC Number：

500-265-7

HScode：

2915709000

Characteristics

PSA：

66.76

XLogP3：

5.1443

Appearance：

Colorless, odorless, and sweet flaky powder

Density：

1.03 g/cm³ @ Temp: 20 °C

Melting Point：

57 °C

Boiling Point：

476.9ºC at 760 mmHg

Flash Point：

151.9ºC

Water Solubility：

insoluble in water; soluble in hot oils, organic solvents

Storage Conditions：

-20ºC

Safety Information

wgk germany：

safety instructions：

24/25

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

Monostearin Use and Manufacturing

Methods of Manufacturing

1, derived from glycerol and stearic acid esterification. Stearic acid, glycerol and sodium hydroxide were added to the reaction kettle, heated and melted and stirred to obtain nitrogen. Heating at 185 ° C for 7 h, the reaction should be at the end of the pH should be less than 5. Cooling out the material, get glycerol monostearate. Per ton of product consumption of stearin greater than 82kg, glycerol (95% or more) 235kg.
2, direct esterification of stearic acid and glycerol according to 1: (1.2 ~ 1 The reaction was carried out at a temperature of 180 to 250 ° C for 2 to 4 hours. The reaction was cooled to 100 ° C and the catalyst was added to the base. After washing with water, the reaction was carried out with 40% ~ 60% of the product. Esterification of glyceryl stearate and glycerol in the presence of 0.06% to 0.1% Cu (OH) 2, at 170 ~ 240 ℃ reaction 1 ~ 2h, the reaction process through the nitrogen for protection, the reaction by deaeration , Acid and refined, refined with a single ester 40% to 60% of the product. Glycerin saponification of glycidic acid and stearic acid in the four ethyl ammonium iodide catalyzed, at 100 ~ 130 ℃ reaction 30 ~ 70min, the reactants refined with a single ester 80% to 90% of the product. Epichlorohydrin phase transfer catalysis epichlorohydrin and sodium stearate (2: 1, molar ratio) in toluene, in the phase transfer catalyst tetrabutyl ammonium bromide catalyzed, at 90 ~ 110 ℃ reaction 2h The reaction was washed with sodium chloride solution, the organic phase was separated, toluene was removed by distillation and unreacted epichlorohydrin was distilled to obtain glycidyl stearate, which was hydrolyzed with 0.1 mol / L NaOH solution, separated and dried , With n-hexane recrystallization products, single ester content of 90% or more. Content of 40% to 60% of the monoester products by molecular distillation can be more than 90% of the high concentration of products.

Uses

1. Lonzest(R) GMS is a surfactant used in a variety of markets.
2. Aldo(R) MS BO KFG is a glycerol ester made from soybean oil derived fatty acid. This product finds uses in both food and cosmetic applications.
3. Aldo(R) MSD KFG is a self emulsifying nonionic surfactant, used as a lubricant in confectionery, as a release agent and as a dough softener. It is used as a low HLB emulsifier in personal care products where non animal grade products are needed.

Material

Hexane

Glycerol

Sodium chloride

Drug Function and Efficacy

This product is a broad-spectrum antifungal drug that can highly selectively inhibit fungal squalene epoxidase, block the squalene epoxidation reaction during the formation of fungal cell membranes and interfere with the early biosynthesis of fungal sterols, thereby exerting the effect of inhibiting and killing fungi.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Massage ointment (massage lotion)
Ingredients	Rue extract, belladonna fluid extract, frankincense, myrrh, chuanxiong, rue, peppermint oil, turmeric, lindera strychnifolia, cinnamon oil, clove oil, camphor, belladonna fluid extract, methyl salicylate, glyceryl monostearate, stearic acid, excipients are glycerin, sodium lauryl sulfate, purified water.
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Terbinafine Hydrochloride Cream
Ingredients	Each vial of this product contains the main ingredient 0.1 gram of terbinafine hydrochloride, and the excipients are: white vaseline, propylene glycol, Tween-80, glyceryl monostearate, and stearic acid.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	10g:0.1g
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Scar removal cream
Ingredients	Peach kernel, Brucea javanica, borneol, camphor, and soda ash; auxiliary ingredients are glycerin, white vaseline, stearyl alcohol, and glyceryl monostearate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	50g per pack

See More Related Drugs

Registered Holders

KERRY Ingredients TRADING(Shanghai) Co., Ltd.

China
Active
Jiangxi Yipusheng Pharmaceutical Co., Ltd.

China
Active
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd.

China
Active

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