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Palonosetron hydrochloride

Palonosetron hydrochloride structure

CAS No:
135729-62-3
Formula:
C19H24N2O.ClH
Chemical Name:
Palonosetron hydrochloride
Synonyms:
1H-Benz[de]isoquinolin-1-one,2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-,hydrochloride (1:1),(3aS)-;1H-Benz[de]isoquinolin-1-one,2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-,monohydrochloride,[S-(R*,R*)]-;1H-Benz[de]isoquinolin-1-one,2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-,monohydrochloride,(3aS)-;RS 25259-197;Palonosetron hydrochloride;Aloxi;Onicit;1021481-16-2
Categories:
Biochemical Engineering > Inhibitors

Description

White SolidChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.Palonosetron is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. Efficacy of palonosetron has been demonstrated i

Palonosetron hydrochloride Basic Attributes

Molecular Weight：

332.86800

Exact Mass：

332.16600

HScode：

2933990090

Characteristics

PSA：

23.55000

XLogP3：

3.33430

Appearance：

White Solid

Melting Point：

>290ºC

Boiling Point：

470.4ºC at 760 mmHg

Flash Point：

209.5ºC

Vapor Pressure：

5.07E-09mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Palonosetron hydrochloride Use and Manufacturing

1. Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
2. Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting
3. Specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.
4. Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Palonosetron Hydrochloride
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Palonosetron Hydrochloride
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Palonosetron Hydrochloride Injection
Specifications	5ml:0.25mg (calculated as C19H24N2O)
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Registered Holders

APITORIA PHARMA PRIVATE LTD

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Guide of Palonosetron hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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