Palonosetron hydrochloride
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Palonosetron hydrochloride
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CAS No:
135729-62-3
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Formula:
C19H24N2O.ClH
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Chemical Name:
Palonosetron hydrochloride
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Synonyms:
1H-Benz[de]isoquinolin-1-one,2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-,hydrochloride (1:1),(3aS)-;1H-Benz[de]isoquinolin-1-one,2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-,monohydrochloride,[S-(R*,R*)]-;1H-Benz[de]isoquinolin-1-one,2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-,monohydrochloride,(3aS)-;RS 25259-197;Palonosetron hydrochloride;Aloxi;Onicit;1021481-16-2
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CAS No:
Description
White SolidChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.Palonosetron is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. Efficacy of palonosetron has been demonstrated i
Characteristics
23.55000
3.33430
White Solid
>290ºC
470.4ºC at 760 mmHg
209.5ºC
5.07E-09mmHg at 25°C
Palonosetron hydrochloride Use and Manufacturing
1. Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
2. Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting
3. Specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.
4. Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]
Drug Function and Efficacy
Extract from the above information
Registered Holders
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APITORIA PHARMA PRIVATE LTD
Active
United States
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ROLABO OUTSOURCING SL
Active
United States
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Rolabo Outsourcing,S.L.
Active
Japan
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