Epsilon-polylysine
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Epsilon-polylysine
structure -
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CAS No:
28211-04-3
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Formula:
C8H18N2O
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Chemical Name:
Epsilon-polylysine
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Synonyms:
epsilon-Polylysin;ε-Polylysine,ε-PL;Poly epsilon L-lysine;Poly[imino[(2S)-2-amino-1-oxo-1,6-hexanediyl]];EPSILON-polylysine,e-Polylysine;poly(L-lysine) macromolecule;ε-poly-L-lysin;ε-poly-L-lysineHC
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CAS No:
Description
from Streptomyces albulus.
A peptide which is a homopolymer of lysine.
ε-Polylysine is a light yellow powder with strong hygroscopicity and slightly bitter taste. It is a linear polymer of lysine. It is produced by streptomyces fermentation and has a broad-spectrum antibacterial effect. ε-polylysine is polymerized by 25-30 lysine groups, which is relatively stable to pH and heat. Its antibacterial effect is related to the degree of polymerization and the environment. The molecular weight of polylysine is between 3600-4300 which has the best antibacterial activity.
In 1977, Japanese scholars S. Shima and H. Sakai, in the process of screening Dragendo~Positive (DP) substances from microorganisms, discovered that a strain of actinomycete No.346 can produce a large amount of stable DP substances. The analysis and structural analysis of the hydrolysate confirmed that the DP substance is a homopolymer of 25-30 lysine residues. A homologous amino acid polymer formed by NH2 condensation, so it is called ε-Poly-L-lysine (ε-Poly-L-lysine for short ε-PL).
ChEBI: A macromolecule composed of repeating L-lysyl units joined via 1,6-amide linkages.
Characteristics
55.12000
ε-PL pure product is light yellow powder, slightly bitter, strong hygroscopicity, and slightly bitter. It is easily soluble in water, slightly soluble in ethanol, but insoluble in organic solvents such as ethyl acetate and ether. It has high stability and antibacterial effect.
0.70500
172 °C
Epsilon-polylysine Use and Manufacturing
Ε-Poly-L-lysine shows antimicrobial activity against gram-positive and negative bacteria.
ε-Poly-L-lysine posess antimicrobial action stronger than alpha-Poly-L-lysine. Studies on the mode of action of ε-PL suggest that adsorption of ε-PL to the bacterial cell surface plays an important role in its antibacterial activity.
Computed Properties
Molecular Weight:158.24
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:158.141913202
Monoisotopic Mass:158.141913202
Topological Polar Surface Area:55.1
Heavy Atom Count:11
Complexity:115
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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