Madecassic acid
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Madecassic acid
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CAS No:
18449-41-7
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Formula:
C30H48O6
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Chemical Name:
Madecassic acid
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Synonyms:
Urs-12-en-28-oic acid,2,3,6,23-tetrahydroxy-,(2α,3β,4α,6β)-;Urs-12-en-28-oic acid,2α,3β,6β,23-tetrahydroxy-;Brahmic acid;(2α,3β,4α,6β)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid;2α,3β,6β,23-Tetrahydroxy-urs-12-en-28-oic acid;Madecassic acid;6β-Hydroxyasiatic acid;NSC 88135;CID 12073158;125265-67-0;2268037-88-1
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CAS No:
Description
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
Characteristics
118.22000
4.00350
1.23 g/cm3
265-268 °C
641.7ºC at 760 mmHg
355.9ºC
1.59
3.61E-19mmHg at 25°C
Madecassic acid Use and Manufacturing
1. Wound healing
2. Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264. 7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Computed Properties
Molecular Weight:504.7
XLogP3:4.4
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:504.34508925
Monoisotopic Mass:504.34508925
Topological Polar Surface Area:118
Heavy Atom Count:36
Complexity:963
Defined Atom Stereocenter Count:10
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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