Astragaloside IV
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Astragaloside IV
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CAS No:
84687-43-4
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Formula:
C41H68O14
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Chemical Name:
Astragaloside IV
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Synonyms:
β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl;1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene,β-D-glucopyranoside deriv.;9,19-Cyclolanostane,β-D-glucopyranoside deriv.;(3β,6α,16β,20R,24S)-20,24-Epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-glucopyranoside;Astragaloside IV;Astrasieversianin XIV;Cyclosiversioside F;Astraversianin XIV;Cyclosieversioside F
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CAS No:
Description
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Characteristics
228 Ų
0.72410
hydroscopic brown or yellow powder
1.39
284-286 °C @ Solvent: Methanol
895.7ºC at 760 mmHg
495.5±34.3 °C
1.621
Astragaloside IV Use and Manufacturing
Astragaloside IV has cardiovascular protective effects, protecting the vascular endothelial cells. In addition it is attributed to have anti0inflammatory and anti-virus effects as well. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.
Computed Properties
Molecular Weight:785.0
XLogP3:1.3
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:784.46090684
Monoisotopic Mass:784.46090684
Topological Polar Surface Area:228
Heavy Atom Count:55
Complexity:1460
Defined Atom Stereocenter Count:17
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Replenish Qi and raise Yang, dilate blood vessels, increase cerebral blood flow, and improve cerebral blood supply
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