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Astragaloside IV

Astragaloside IV structure

CAS No:
84687-43-4
Formula:
C41H68O14
Chemical Name:
Astragaloside IV
Synonyms:
β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl;1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene,β-D-glucopyranoside deriv.;9,19-Cyclolanostane,β-D-glucopyranoside deriv.;(3β,6α,16β,20R,24S)-20,24-Epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-glucopyranoside;Astragaloside IV;Astrasieversianin XIV;Cyclosiversioside F;Astraversianin XIV;Cyclosieversioside F
Categories:
Biochemical Engineering > Chinese Herbs

Description

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

Astragaloside IV Basic Attributes

Molecular Weight：

784.97

Exact Mass：

784.97

EC Number：

617-610-3

HScode：

2932999099

Characteristics

PSA：

228 Å²

XLogP3：

0.72410

Appearance：

hydroscopic brown or yellow powder

Density：

1.39

Melting Point：

284-286 °C @ Solvent: Methanol

Boiling Point：

895.7ºC at 760 mmHg

Flash Point：

495.5±34.3 °C

Refractive Index：

1.621

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

Drug Information

MeSH Entry Terms：

3beta,6alpha,16beta,20R,24S; astragaloside IV of astragaloside A

Astragaloside IV Use and Manufacturing

Astragaloside IV has cardiovascular protective effects, protecting the vascular endothelial cells. In addition it is attributed to have anti0inflammatory and anti-virus effects as well. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.

Computed Properties

Molecular Weight:785.0
XLogP3:1.3
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:784.46090684
Monoisotopic Mass:784.46090684
Topological Polar Surface Area:228
Heavy Atom Count:55
Complexity:1460
Defined Atom Stereocenter Count:17
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Replenish Qi and raise Yang, dilate blood vessels, increase cerebral blood flow, and improve cerebral blood supply

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naoluotong Capsule
Ingredients	Danshen extract, Tolperisone hydrochloride, Chuanxiong extract, Methyl hesperidin, Astragalus extract, Vitamin B6
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 0.5g (containing 50mg of Tolperisone hydrochloride)
Manufacturer	Henan Furentang Pharmaceutical Co., Ltd.

Naoluotong Capsule
Ingredients	Salvia miltiorrhiza extract, Chuanxiong extract, Astragalus extract, methyl hesperidin, tolperisone hydrochloride, vitamin B.
Indication	Drug interactions may occur if used with other drugs. Please consult your pharmacist or doctor for details.
Specifications	Each tablet contains 0.5g (containing 50mg of Tolperisone hydrochloride)

Naoluotong Capsule
Ingredients	Salvia miltiorrhiza extract, Chuanxiong extract, Astragalus extract, methyl hesperidin, tolperisone hydrochloride, vitamin B.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 0.5g (containing 50mg of Tolperisone hydrochloride)

See More Related Drugs

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Astragaloside I Structure

84680-75-1
Astragaloside III Structure

84687-42-3
What is Astragaloside VI

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Guide of Astragaloside IV

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Learn More Other Chemicals

Astragaloside IV

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