 Home > Encyclopedia > Lercanidipine

Lercanidipine

Lercanidipine structure

CAS No:
100427-26-7
Formula:
C36H41N3O6
Chemical Name:
Lercanidipine
Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester;Masnidipine;Lercanidipine;Zanidip;2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl] ester 5-methyl ester
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular ri

Solid

Lercanidipine is a diarylmethane.|Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.

Lercanidipine Basic Attributes

Molecular Weight：

611.72700

Exact Mass：

611.73

DSSTox ID：

DTXSID2048327

ATC Code：

C08CA13|C - Cardiovascular system

HScode：

2942000000

Characteristics

PSA：

113.69000

XLogP3：

7.33040

Appearance：

Solid

Density：

1.177 g/cm3

Melting Point：

118-120ºC

Boiling Point：

712.5ºC at 760 mmHg

Flash Point：

384.7ºC

Refractive Index：

1.579

Water Solubility：

1.56e-04 g/L

Vapor Pressure：

3.77E-20mmHg at 25°C

Collision Cross Section：

249.8 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Safety Information

Precautionary statement(s)：

P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501

Hazard Statements：

H302

Drug Information

Drug Indication：

For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome

Pharmacology：

Lercanidipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Lercanidipine is similar to other peripheral vasodilators. Lercanidipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

Mechanism of Action：

By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

MeSH Entry Terms：

Lercadip

Computed Properties

Molecular Weight:611.7
XLogP3:6.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:611.29953604
Monoisotopic Mass:611.29953604
Topological Polar Surface Area:114
Heavy Atom Count:45
Complexity:1090
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

In Europe, this product is used for various types of hypertension; in the UK it is only used for mild to moderate hypertension.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lercanidipine Hydrochloride Tablets
Ingredients	Lercanidipine
Indication	This product should be used with caution when used in combination with drug enzyme inhibitors such as ketoconazole, itraconazole, erythromycin, fluoxetine; or drug enzyme inducers such as phenytoin, itraconazole, erythromycin, fluoxetine; and drug enzyme substrates such as terfenadine, astemizole, cyclosporine, amiodarone, quinidine, diazepam, midazolam, propranolol and metoprolol. In addition, this product should not be used in combination with grapefruit juice to avoid adverse reactions due to increased blood drug concentration.
Specifications	10mg
Manufacturer	Chongqing Shenghuaxi Pharmaceutical. Co., Ltd.

Lercanidipine Hydrochloride Tablets
Ingredients	Lercanidipine
Indication	This product should be used with caution when used in combination with drug enzyme inhibitors such as ketoconazole, itraconazole, erythromycin, fluoxetine; or drug enzyme inducers such as phenytoin, itraconazole, erythromycin, fluoxetine; and drug enzyme substrates such as terfenadine, astemizole, cyclosporine, amiodarone, quinidine, diazepam, midazolam, propranolol and metoprolol. In addition, this product should not be used in combination with grapefruit juice to avoid adverse reactions due to increased blood drug concentration.
Specifications	10 mg

Recommended Suppliers of Lercanidipine

Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

Lercanidipine

CAS No.: 100427-26-7

Grade: industrial Grade

Content: 98%

Inquiry
Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

High Quality Lercanidipine powder Raw Materials CAS:100427-26-7 with Best Price!

CAS No.: 100427-26-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Wuhan Dienle Technology Co., Ltd Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of Pharmaceutical intermediate/API， and fragrances API

Lercanidipine CAS:100427-26-7

CAS No.: 100427-26-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry