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DRONEDARONE HYDROCHLORIDE

DRONEDARONE HYDROCHLORIDE structure

CAS No:
141625-93-6
Formula:
C31H44N2O5S.ClH
Chemical Name:
DRONEDARONE HYDROCHLORIDE
Synonyms:
Multaq;N-(2-butyl-3-{4-[3-(dibutylaMino)propoxy]benzoyl}-1-benzofuran-5-yl)MethanesulfonaMide hydrochloride (1:1);N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-benzofuran-5-yl)methanesulfonamide hydrochlorid;Dronedarone Hydrocholoride;CS-132;Dronedarone hydrochloride, ≥98% (HPLC);N-[2-butyl-3-[4-(3-dibutyl-aminopropoxy) benzoyl] methanesulfonamide hydrochloride;SR-33589B
Categories:
Biochemical Engineering > Inhibitors

Description

Dronedarone hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.

Pale Yellow Solid

DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.

DRONEDARONE HYDROCHLORIDE Basic Attributes

Molecular Weight：

593.224

Exact Mass：

592.273743

EC Number：

630-355-2

UNII：

FA36DV299Q

DSSTox ID：

DTXSID30161779

Color/Form：

white to off-white

HScode：

2935904000

Characteristics

PSA：

97.2

XLogP3：

9.00480

Appearance：

white to off-white

Melting Point：

NA (low-melting)

Boiling Point：

683.9ºC at 760mmHg

Flash Point：

367.4ºC

Water Solubility：

DMSO: soluble15mg/mL, clear

Storage Conditions：

Refrigerator

Vapor Pressure：

1.47E-18mmHg at 25°C

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

Precautionary statement(s)：

P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501

Hazard Statements：

H302

RIDADR：

UN 3077 9 / PGIII

GHS Classification：

|Danger|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 13 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

DRONEDARONE HYDROCHLORIDE Use and Manufacturing

Uses

A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.

Cardiovascular Drugs

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:593.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:18
Exact Mass:592.2737714
Monoisotopic Mass:592.2737714
Topological Polar Surface Area:97.2
Heavy Atom Count:40
Complexity:800
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dronedarone Hydrochloride Tablets
Ingredients	Dronedarone hydrochloride. Chemical name: N-(2-butyl-3-(4-(3-dibutylaminopropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride Molecular weight: C31H44N2O5S·HCl
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	400mg

Dronedarone Hydrochloride Tablets
Specifications	400 mg (based on C31H44N2O5 tablets)

Dronedarone Hydrochloride Tablets
Specifications	400 mg (based on C31H44N2O5 tablets)

See More Related Drugs

Registered Holders

AURORE LIFE SCIENCES PRIVATE LTD

United States
Active
RAKS PHARMA PVT LTD

United States
Active
MSN LABORATORIES PRIVATE LTD

United States
Active

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Guide of DRONEDARONE HYDROCHLORIDE

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

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