DRONEDARONE HYDROCHLORIDE
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DRONEDARONE HYDROCHLORIDE
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CAS No:
141625-93-6
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Formula:
C31H44N2O5S.ClH
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Chemical Name:
DRONEDARONE HYDROCHLORIDE
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Synonyms:
Multaq;N-(2-butyl-3-{4-[3-(dibutylaMino)propoxy]benzoyl}-1-benzofuran-5-yl)MethanesulfonaMide hydrochloride (1:1);N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-benzofuran-5-yl)methanesulfonamide hydrochlorid;Dronedarone Hydrocholoride;CS-132;Dronedarone hydrochloride, ≥98% (HPLC);N-[2-butyl-3-[4-(3-dibutyl-aminopropoxy) benzoyl] methanesulfonamide hydrochloride;SR-33589B
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CAS No:
Description
Dronedarone hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
Pale Yellow Solid
DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.
DRONEDARONE HYDROCHLORIDE Basic Attributes
593.224
592.273743
630-355-2
FA36DV299Q
DTXSID30161779
white to off-white
2935904000
Characteristics
97.2
9.00480
white to off-white
NA (low-melting)
683.9ºC at 760mmHg
367.4ºC
DMSO: soluble15mg/mL, clear
Refrigerator
1.47E-18mmHg at 25°C
2-8°C
Safety Information
UN 3077 9 / PGIII
3
P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501
H302
UN 3077 9 / PGIII
|Danger|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 13 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
DRONEDARONE HYDROCHLORIDE Use and Manufacturing
A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.
Cardiovascular Drugs
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:593.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:18
Exact Mass:592.2737714
Monoisotopic Mass:592.2737714
Topological Polar Surface Area:97.2
Heavy Atom Count:40
Complexity:800
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Not yet clear
Registered Holders
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AURORE LIFE SCIENCES PRIVATE LTD
Active![United States]()
United States
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RAKS PHARMA PVT LTD
Active![United States]()
United States
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MSN LABORATORIES PRIVATE LTD
Active![United States]()
United States
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