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Huperzine A

Huperzine A structure

CAS No:
102518-79-6
Formula:
C15H18N2O
Chemical Name:
Huperzine A
Synonyms:
5,9-Methanocycloocta[b]pyridin-2(1H)-one,5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-,(5R,9R,11E)-;5,9-Methanocycloocta[b]pyridin-2(1H)-one,5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-,[5R-(5α,9β,11E)]-;Selagine;(5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one;Huperzine A;(-)-Huperzine A;(-)-Selagine;Kimpukan A;Hupzine A;Hup A;Huperzine;116-28-9;1369-64-8;475473-11-1
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be

Huperzine A Basic Attributes

Molecular Weight：

242.31600

Exact Mass：

242.32

EC Number：

600-320-6

DSSTox ID：

DTXSID8046038

HScode：

2933990090

Characteristics

PSA：

58.88000

XLogP3：

2.69780

Appearance：

white to slight white crystaline powder

Density：

1.2 g/cm3

Melting Point：

224-226 °C

Boiling Point：

505ºC at 760 mmHg

Flash Point：

259.2ºC

Refractive Index：

1.626

Storage Conditions：

-20ºC

Safety Information

Packing level：

Ⅱ

Transport codes：

UN 1544 6.1/PG 2

wgk germany：

hazard class code：

R26/27/28; R36/37/38

safety instructions：

S26; S36/37/39; S45

RTECS Number：

PB9185700

Marks：

T+

Precautionary statement(s)：

P260-P264-P280-P284-P301 + P310-P302 + P350

Hazard Statements：

H300 + H310 + H330-H315-H319-H335

GHS Classification：

|Danger|H300 (20.81%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 197 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

MeSH Entry Terms：

huperzine A

Huperzine A Use and Manufacturing

Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cere

Computed Properties

Molecular Weight:242.32
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:242.141913202
Monoisotopic Mass:242.141913202
Topological Polar Surface Area:55.1
Heavy Atom Count:18
Complexity:551
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a cholinesterase inhibitor, which has a selective inhibitory effect on true ChE and can easily pass through the blood-brain barrier. It has the effect of promoting memory reproduction and enhancing memory retention.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Huperzine A
Ingredients	The main component of this product is: Huperzine A. Its chemical name is: (5R, 9R, 11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methylenecyclooctanol(b)pyridine-2(1H)one. Molecular formula: C15H18N2O Molecular weight: 242.32
Indication	Not yet clear.
Specifications	50ug
Manufacturer	Hainan Simcere Pharmaceutical Co., Ltd.

Huperzine A

Secnidazole tablets
Ingredients	The main component is Huperzine A. Chemical name: (5R, 9R, 11E)-5-amino-11-ethylidene-5,8,9,10-tetrahydro-7-methyl-5,9-methylenecyclooctatetraen[b]pyridin-2-(1H)-one.
Indication	Not yet clear.
Specifications	0.5g

See More Related Drugs

Registered Holders

Wanbangde Pharmaceutical Group Co., Ltd.

China
Active
Ningbo GREEN-HEALTH Pharmaceutical Co., Ltd.

China
Active
Ningbo Liwah Pharmaceutical Co., Ltd.

China
Active

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