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D-Alanine

D-Alanine structure

CAS No:
338-69-2
Formula:
C3H7NO2
Chemical Name:
D-Alanine
Synonyms:
D-Alanine;Alanine,D-;Ba 2776;D-(-)-Alanine;D-α-Alanine;D(-)-α-Alanine;(R)-Alanine;NSC 158286;(2R)-2-Aminopropanoic acid;(R)-2-Aminopropanoic acid;2: PN: RU2506269 PAGE: 13 claimed sequence
Categories:
Biochemical Engineering > Amino Acids and Proteins

Description

D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

Solid

D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.|The D-enantiomer of alanine.|A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.

D-Alanine Basic Attributes

Molecular Weight：

89.09

Exact Mass：

89.09

BRN：

1720249

EC Number：

206-418-1

UNII：

E3UDS4613U

DSSTox ID：

DTXSID3045649

HScode：

29224995

Characteristics

PSA：

63.3

XLogP3：

-3

Appearance：

White to off-white Crystalline Powder or Crystals

Density：

1.432 g/cu cm at 22 deg C

Melting Point：

292 °C

Boiling Point：

250 deg C (sublimes)

Flash Point：

82.6±22.6 °C

Refractive Index：

1.460

Water Solubility：

H2O: 155 g/L (20 ºC)

Storage Conditions：

Store at RT.

Vapor Pressure：

1.05X10-7 mm Hg at 25 deg C (est)

Specific rotation：

-14.5 º (c=10, 6N HCl)

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

24/25-36-26

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Drug Information

Drug Indication：

Treatment of Multiple Myeloma|Parenteral nutrition

MeSH Entry Terms：

Abufène

D-Alanine Use and Manufacturing

Methods of Manufacturing

Using N-acetyl-DL-alanine as raw material, it is obtained by acylase resolution to remove L-alanine, hydrochloric acid hydrolysis, and recrystallization.

Uses

D-alanine is an important organic chiral source, mainly used in chiral drugs.Alanine is mainly used to synthesize pantothenic acid and calcium pantothenate, carnosine, pamidronate, balsalazide, etc., and is widely used in medicine, feed, food and other fields. Also used in electroplating corrosion inhibitors and biochemical reagents.Raw material for the synthesis of new sweeteners and some chiral drug intermediates

Manufacturing Info：

D-Alanine: ACTIVE

Use Classification：

Human Drugs -> EU pediatric investigation plans|Cosmetics -> Antistatic

Computed Properties

Molecular Weight:89.09
XLogP3:-3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:89.047678466
Monoisotopic Mass:89.047678466
Topological Polar Surface Area:63.3
Heavy Atom Count:6
Complexity:61.8
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Glycine

Drug Function and Efficacy

Regulate the balance of amino acid metabolism in the body, reduce inflammation, swelling and shrink the prostate

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Glutamate capsules
Ingredients	This product is a compound preparation, each tablet contains 0.265g of glutamic acid, 0.1g of alanine, and 45mg of glycine.
Indication	The experiment was not conducted and there is no reliable reference
Specifications	Each capsule contains 0.265g of glutamic acid, 0.1g of alanine, and 45mg of glycine
Manufacturer	Shaanxi Tangwang Tianyang Pharmaceutical Co., Ltd.

Compound Amino Acid Oral Solution (14AA)
Ingredients	This product is a compound preparation, and its components are as follows: each bottle contains 0.688g leucine, 0.563g isoleucine, 0.525g valine, 0.563g glycine, 0.500g proline, 0.481g alanine, 0.476g lysine (HCl), 0.375g arginine (base), 0.313g serine, 0.281g threonine, 0.150g histidine (base), 0.063g methionine, 0.063g phenylalanine, and 0.041g tryptophan.
Indication	Not yet clear.
Specifications	Each bottle is 50 ml (containing 5.082 grams of amino acids in total)
Manufacturer	Hubei Provincial Bafeng Pharmaceuticals & CHEMICALS SHARE Co., Ltd.

Glutamate capsules
Ingredients	Glutamic acid 0265g, alanine 01g, glycine 45mg.
Indication	Not yet clear.
Specifications	Glutamic acid 0.265g, alanine 0.1g, glycine 45mg
Manufacturer	Liaoning Shengjing Huabang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Yuanda Bafeng (Hubei) Pharmaceutical Co., Ltd.

China
Active
Shanghai Primano Amino Acid Co., Ltd.

China
Active
Zhangjiagang Huachang Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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Guide of D-Alanine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Downstream Products
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

D-Alanine

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