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Naproxen

Naproxen structure

CAS No:
22204-53-1
Formula:
C14H14O3
Chemical Name:
Naproxen
Synonyms:
2-Naphthaleneacetic acid,6-methoxy-α-methyl-,(αS)-;2-Naphthaleneacetic acid,6-methoxy-α-methyl-,(+)-;2-Naphthaleneacetic acid,6-methoxy-α-methyl-,(S)-;(αS)-6-Methoxy-α-methyl-2-naphthaleneacetic acid;(+)-2-(6-Methoxy-2-naphthyl)propionic acid;Naproxen;(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid;d-2-(6-Methoxy-2-naphthyl)propionic acid;d-Naproxen;CG 3117;Naprosyn;Equiproxen;Naixan;(+)-Naproxen;(S)-(+)-Naproxen;(S)-Naproxen;(+)-(S)-Naproxen;(S)-2-(6-Methoxy-2-naphthyl)propionic acid;(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid;(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid;(S)-2-(6-Methoxy-2-naphthyl)propanoic acid;(S)-(+)-Naproxene;Apo-Naproxen;Diocodal;RS 3540;Laraflex;Naprosyne;Naxen;MNPA;Naprux;Laser;Bonyl;Napren;Floginax;Veradol;Proxen;Panoxen;Proxine;Xenar;Dysmenalgit;Reuxen;Nycopren;Prexan;Naprium;Naprius;(S)-α-Methyl-6-methoxynaphthalene-2-acetic acid;Aproxen;(S)-2-(6-Methoxynaphthalen-2-yl)propionic acid;(S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid;Xenar-CR;(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid;(+)-(S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid;(2S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
Categories:
Cosmetic Ingredient > Skin Conditioning

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Description

Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.

Naproxen Basic Attributes

Molecular Weight：

230.26

Exact Mass：

230.26

BRN：

3591067

EC Number：

244-838-7

HScode：

2918990090

Characteristics

PSA：

46.5

XLogP3：

3.3

Appearance：

Solid

Density：

1.24 g/cm³

Melting Point：

152-154 °C

Boiling Point：

403.8°C at 760 mmHg

Flash Point：

9℃

Refractive Index：

1.609

Water Solubility：

Insoluble in water.

Storage Conditions：

-20°C Freezer

Vapor Pressure：

1.89X10-6 mm Hg at 25 deg C (est)

Toxicity：

Oral-Rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg

Flammability characteristics：

Flammable; burning produces toxic and spicy irritating smoke

Specific rotation：

D +66° (in chloroform)

Odor：

Practically odorless

PKA：

4.15None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

22-39/23/24/25-23/24/25-11-36/37/38

safety instructions：

36/37-45-16-7-26

RTECS Number：

UF5275000

Marks：

Xn,T,F

Storage features：

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

Toxicity

Toxicity class：

highly

Naproxen Use and Manufacturing

Methods of Manufacturing

Using 2-naphthol through methylation and acetylation to obtain 6-methoxy-2-naphthyl ethyl ketone, then condensed with chloroacetate, and then subjected to isomerization, hydrolysis, oxidation, neutralization, resolution and other reactions be made of.

Uses

An anti-inflammatory, analgesic, antipyretic.A non-steroidal anti-inflammatory.This product is a non-steroidal anti-inflammatory antipyretic analgesic. It can be used for chronic arthritis, deformed arthritis, low back pain, acute upper respiratory tract inflammation, as well as anti-inflammatory and analgesic after tooth extraction and minor surgery. Used as an anti-inflammatory analgesic. Used as an intermediate for pharmaceutical naproxen. A non-steroidal anti-inflammatory analgesic used to relieve fever and inflammation and pain associated with arthritis or other symptoms, with anti-inflammatory, antipyretic and analgesic effects. Naproxen works by inhibiting cyclooxygenase, an enzyme involved in the production of prostaglandins, an inflammatory mediator. It is recommended to take this medicine with meals to reduce stomach irritation.

Computed Properties

Molecular Weight:230.26
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:230.094294304
Monoisotopic Mass:230.094294304
Topological Polar Surface Area:46.5
Heavy Atom Count:17
Complexity:277
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a non-steroidal anti-inflammatory drug. Its analgesic, anti-inflammatory and antipyretic effects work by inhibiting the synthesis of prostaglandins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naproxen Capsules
Ingredients	The main ingredient of this product is naproxen. Its chemical name is ()-alpha;-methyl-6-methoxy-2-naphthylacetic acid. Molecular formula: C14H14O3 Molecular weight: 230.26
Indication	1. When drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. 2. When used with anticoagulants such as heparin and dicoumarol, the bleeding time is prolonged. Bleeding tendency may occur and there is a possibility of causing gastrointestinal ulcers. 3. This product can reduce the sodium excretion and hypotensive effect of furosemide. 4. This product can inhibit the excretion of lithium in urine and increase the blood concentration of lithium. 5. When used with probenecid, the blood concentration of this product increases and T1/2 is prolonged. It can increase the efficacy, but the toxic reaction is also increased accordingly.
Specifications	0.2g
Manufacturer	Wuhan Jiu'an Pharmaceutical Co., Ltd.

Naproxen Capsules
Ingredients	The main ingredient of this product is naproxen. Its chemical name is ()-alpha;-methyl-6-methoxy-2-naphthylacetic acid. Molecular formula: C14H14O3 Molecular weight: 230.26
Indication	1. When drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. 2. When used with anticoagulants such as heparin and dicoumarol, the bleeding time is prolonged. Bleeding tendency may occur and there is a possibility of causing gastrointestinal ulcers. 3. This product can reduce the sodium excretion and hypotensive effect of furosemide. 4. This product can inhibit the excretion of lithium in urine and increase the blood concentration of lithium. 5. When used with probenecid, the blood concentration of this product increases and T1/2 is prolonged. It can increase the efficacy, but the toxic reaction is also increased accordingly.
Specifications	0.125g
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

Naproxen Capsules
Ingredients	The main ingredient of this product is naproxen. Its chemical name is ()-alpha;-methyl-6-methoxy-2-naphthylacetic acid. Molecular formula: C14H14O3 Molecular weight: 230.26
Indication	1. When drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. 2. When used with anticoagulants such as heparin and dicoumarol, the bleeding time is prolonged. Bleeding tendency may occur and there is a possibility of causing gastrointestinal ulcers. 3. This product can reduce the sodium excretion and hypotensive effect of furosemide. 4. This product can inhibit the excretion of lithium in urine and increase the blood concentration of lithium. 5. When used with probenecid, the blood concentration of this product increases and T1/2 is prolonged. It can increase the efficacy, but the toxic reaction is also increased accordingly.
Specifications	0.125g
Manufacturer	Anhui Guozheng Pharmaceutical Co., Ltd.

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Registered Holders

HETERO LABS LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
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Dr.Reddy’s Laboratories Limited office and manufacturing site in Mexico

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