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Omeprazole

Omeprazole structure

CAS No:
73590-58-6
Formula:
C17H19N3O3S
Chemical Name:
Omeprazole
Synonyms:
1H-Benzimidazole,6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-;1H-Benzimidazole,5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-;6-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole;Omeprazole;H 168/68;Losec;Prilosec;Audazol;Aulcer;Belmazol;Ceprandal;Elgam;Emeproton;Gastrimut;Indurgan;Miol;Mopral;Omapren;Ompanyt;Parizac;Pepticum;Prysma;Sanamidol;Secrepina;Ulceral;Ulcesep;Ulcometion;Zimor;Omepral;Gastrozole;(±)-Omeprazole;Antra;Antra MUPS;Ultop;2-[[(3,5-Dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole;Omebeta 20;Dizprazol;Dudencer;Epirazole;Gastroloc;Gibancer;Acidex;Desec;Logastric;Lomac;Miracid;Ocid;Omed;Omedar;OMEP;Omepril;Omeprazon;Omezol;Omezzol;Omid;Omizac;Omisec;OMP;OMZ;Oprax;Opraz;Ozoken;Peptilcer;Prazidec;Ramezol;Roweprazol;Ulcozol;Ulsen;Ulzone;Zefxon;Zoltum;Inhibitron;Inhipump;Omepradex;Mepral;Omeprazen;5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole;GastroGard;Megazole;Omeprol;Omeprazole-Towa;Ovulanze;Omerap;Emilok;5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole;Omelac;Petprazol 20;Equiprazole;Zegerid;Gastroguard;RS-omeprazole;131959-78-9;172964-80-6
Categories:
Pharmaceutical Intermediates > Gastrointestinal Agents

Description

Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.Target: Proton PumpOmeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1

Omeprazole Basic Attributes

Molecular Weight：

345.42

Exact Mass：

345.42

EC Number：

201-212-8

HScode：

29333990

Characteristics

PSA：

96.3

XLogP3：

2.2

Appearance：

white solid

Density：

1.332 g/cm³

Melting Point：

156 °C

Boiling Point：

600°C at 760 mmHg

Flash Point：

9℃

Refractive Index：

1.669

Water Solubility：

soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).

Storage Conditions：

2-8°C

Vapor Pressure：

9.2X10-13 mm Hg at 25 deg C /Estimated/

Toxicity：

LD50 in mice, rats (g/kg): 0.08, >0.05 i.v.; >4, >4 orally (Ekman)

PH：

Weak base

PKA：

9.29(acid), 4.77 (base)

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

36/37/38-39/23/24/25-23/24/25-11

safety instructions：

26-36-37/39-45-36/37-16-7

RTECS Number：

DD9087000

Marks：

Xi,T,F

Stability/Shelf Life：

Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Omeprazole Use and Manufacturing

Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus)

Computed Properties

Molecular Weight:345.4
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:345.11471265
Monoisotopic Mass:345.11471265
Topological Polar Surface Area:96.3
Heavy Atom Count:24
Complexity:453
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Amoxicillin

Benzimidazole

m-Chloroperbenzoic acid

o-Phenylenediamine

Drug Function and Efficacy

Proton pump inhibitor. This product is a fat-soluble weak alkaline drug that is easily concentrated in an acidic environment. After oral administration, it can be specifically distributed in the secretory tubules of the gastric mucosal parietal cells and converted into the active form of sulfenamide in this high-acid environment. Then, it irreversibly combines with the sulfhydryl group of the H, K-ATPase (also known as the proton pump) in the secretory membrane of the parietal cells through a disulfide bond to form a complex of sulfenamide and the proton pump, thereby inhibiting the activity of the enzyme and blocking the final step of gastric acid secretion. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Omeprazole enteric-coated capsules
Ingredients	The main ingredient of this product is omeprazole.
Indication	This product can delay the elimination of drugs metabolized by the liver in the body, such as diazepam, phenytoin sodium, warfarin, nifedipine, etc. When this product is used together with the above-mentioned drugs, the dosage of the latter should be reduced.
Specifications	20mg
Manufacturer	Hainan Poly Pharm. Co., Ltd.

Omeprazole enteric-coated capsules
Ingredients	Omeprazole.
Indication	1. Avoid simultaneous use with oral imidazole antifungal drugs such as ketoconazole, itraconazole, miconazole and fluconazole; 2. The combined use of omeprazole and clarithromycin can increase the incidence of adverse reactions of the central nervous system (mainly headache) and gastrointestinal tract; 3. Avoid simultaneous use with diazepam (Valium), phenytoin, warfarin, nifedipine, digoxin, cisapride, quinidine, cyclosporine, caffeine and theophylline; 4. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	20mg
Manufacturer	Shanxi Jinhuahuixing Pharmaceutical. Co., Ltd.

Omeprazole enteric-coated capsules
Ingredients	The main ingredient of this product is omeprazole.
Indication	This product can delay the elimination of drugs metabolized by the liver in the body, such as diazepam, phenytoin sodium, warfarin, nifedipine, etc. When this product is used together with the above-mentioned drugs, the dosage of the latter should be reduced.
Specifications	20mg
Manufacturer	Foshan Palm Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhejiang Gold Pharma Co., Ltd.

China
Active
SRINI PHARMACEUTICALS PRIVATE LTD

United States
Active
CHROMO LABORATORIES INDIA PRIVATE LTD

United States
Active

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