Pitavastatin calcium
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Pitavastatin calcium
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CAS No:
147526-32-7
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Formula:
C25H24FNO4.1/2Ca
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Chemical Name:
Pitavastatin calcium
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Synonyms:
6-Heptenoic acid,7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,calcium salt (2:1),(3R,5S,6E)-;6-Heptenoic acid,7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,calcium salt (2:1),[S-[R*,S*-(E)]]-;NK 104;NK 104 (acid);Pitavastatin hemicalcium;(E)-(3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid hemicalcium salt;Livalo;Pitavastatin calcium;Pitava 1;Pitava;Flovas;Calcium (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate;1187847-92-2;1316291-17-4
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Pitavastatin Calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells.
Pitavastatin calcium Use and Manufacturing
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore,A23187.
Drug Function and Efficacy
Extract from the above information
Registered Holders
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MATRIX PHARMACORP PRIVATE LTD
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United States
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APITORIA PHARMA PRIVATE LTD
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United States
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ZYDUS LIFESCIENCES LTD
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United States
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