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Ceftazidime pentahydrate

Ceftazidime pentahydrate structure

CAS No:
78439-06-2
Formula:
C22H22N6O7S2.5H2O
Chemical Name:
Ceftazidime pentahydrate
Synonyms:
Pyridinium,1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt,hydrate (1:5);Pyridinium,1-[[7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt,pentahydrate,[6R-[6α,7β(Z)]]-;Pyridinium,1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt,pentahydrate;Ceftazidime pentahydrate;Glazidim;Starcef 1;Cefidime;Ceftadizim
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Ceftazidime pentahydrate (GR20263 pentahydrate) is a third generation cephalosporin administered intravenously or intramuscularly. Ceftazidime pentahydrate has a broad spectrum of in vitro activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is particularly active against Enterobacteriaceae (including beta-lactamase-positive strains) and is resistant to hydrolysis by most beta-lactamases[1].

Ceftazidime pentahydrate Basic Attributes

Molecular Weight：

636.65

Exact Mass：

546.099121

EC Number：

276-715-9

HScode：

29419000

Characteristics

PSA：

244.76000

XLogP3：

-2.84

Appearance：

white to cream-colored crystalline powder

Melting Point：

>1500C (dec.)

Water Solubility：

Sparingly soluble in aqueous solution

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43

safety instructions：

22-36/37-45-37-24

RTECS Number：

UU2230000

Marks：

Drug Information

Drug Indication：

Treatment of Gram-negative bacterial infections, Treatment of intra-abdominal infections, Treatment of pneumonia, Treatment of urinary tract infections

Ceftazidime pentahydrate Use and Manufacturing

Uses

Third generation cephalosporin antibiotic. Antibacterial.

Use Classification：

Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:546.6
XLogP3:0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:8
Exact Mass:546.09913941
Monoisotopic Mass:546.09913941
Topological Polar Surface Area:245
Heavy Atom Count:37
Complexity:1020
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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