Glucuronolactone
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Glucuronolactone
structure -
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CAS No:
32449-92-6
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Formula:
C6H8O6
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Chemical Name:
Glucuronolactone
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Synonyms:
D-Glucuronic acid,γ-lactone;Glucuronic acid,γ-lactone,D-;Glucurone;Glucuronolactone;Glucurolactone;D-Glucuronolactone;D-Glucurono-γ-lactone;D-Glucurono-6,3-lactone;Glucuronic acid γ-lactone;Glucoxy;Guronsan;Dicurone;Glycurone;Reulatt S.S.;Glucuronosan;D-Glucurono-3,6-lactone;D-Glucuronic acid lactone;D-Glucofuranurono-6,3-lactone;Glucurono-6,3-lactone;NSC 656;D-Glucuronic acid γ-lactone;4214-08-8;6814-06-8;10030-64-5;3428-13-5
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CAS No:
Characteristics
104
-2.80660
White Crystals or Crystalline Powder
1.75 g/cm3 @ Temp: 25 °C
177.5 °C
488.9°C at 760 mmHg
174.9±17.5 °C
1.597
water: soluble 25mg/mL, clear, colorless
Store at RT.
Oral-rat LD50: 10700 mg/kg; Oral-Mouse LD50: >20000 mg/kg
Flammable; burning produces irritating fumes
19 º (c=10, H2O)
Safety Information
NONH for all modes of transport
2
36/37/38
24/25-36-26
LZ8930000
Xi
Warehouse ventilated, low temperature and dry
Stable under normal temperatures and pressures.
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Glucuronolactone Use and Manufacturing
Oxidation is fed according to the ratio of starch (m): nitric acid (67% ± 0.5%, V): water (V) = 1: 1.5: 8.5. First put nitric acid into the oxidation kettle, start stirring, and heat to 60℃. Add starch, (2% of the total amount), raise the temperature to 78°C within 15min for initiation, hold for 5min, then cool down to 50-60°C within 15min, add starch every 20min, divided into two (30% of the total amount) Finally, at a temperature of 47 ℃ ± 1 ℃, add starch every 25min, divided into four times (68% of the total amount). Control the temperature to increase the average temperature of the reaction by 5°C per hour, keep it for 7-8h, the temperature reaches 68°C, discharge, add water (12% of the total amount) to the liquid, heat it with steam at 70-80°C, remove NO2 within 20min, After standing, add water (88% of the total amount) to obtain carboxy starch liquid. Starch [HNO3, starch, water] → [47℃±1℃, 7-8h] Hydrolysis of hydroxy starch liquid The carboxyl starch liquid is pumped into the hydrolysis tank, steam is heated to 100 ℃, and yellow smoke and water vapor come out. Then sealed, the internal pressure increased to 245.25kPa (2.5kgf/cm2), the temperature was 140-142 ℃, hydrolyzed for 2h, to obtain a hydrolysate, that is, a glucuronic acid solution. Hydroxy starch liquid [245kPa]→[140-142℃, 2h] hydrolyzate (glucuronic acid) lactonized. The above hydrolysate was decolorized by 122 weakly acidic cation exchange resin. The decolorized liquid was pumped into the concentration tank under vacuum The temperature is about 93.33 kPa (700mmHg), below 50-60°C, and concentrated under reduced pressure until 34-36°Be. Add 1.68 times the amount of starch glacial acetic acid into the concentrated solution, place it in an esterification tank, esterify at room temperature for 16-24h, let cool to 0-5℃ for crystallization, and filter to obtain crude glucuronolactone. Hydrolysate [112 type resin, ice HAc] → [16-24h] Refining crude glucuronolactone According to crude product (m): distilled water (V): ethanol (V): activated carbon (m) = 1: 0.7: 0.4: 0.01-0.03 ratio of feeding. Put the crude product and distilled water in a refining tank, heat and stir continuously to make it completely dissolved, add activated carbon to decolorize, then add ethanol, stir evenly, suction filter, the filtrate is cooled to 0-5 ℃, put it for 16h, spin filter, filter cake Wash once with absolute ethanol, spin dry, and dry below 80 ℃, that is, glucuronolactone boutique. Crude glucuronolactone [distilled water, ethanol, activated carbon] → [0-5℃, 16h] glucuronolactone boutique.
A glucuronic acid derivative. It is used for treating canine hepatitis.
D-Glucuronic acid, .gamma.-lactone: ACTIVE
Cosmetics -> Skin conditioning
Computed Properties
Molecular Weight:176.12
XLogP3:-1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:176.03208797
Monoisotopic Mass:176.03208797
Topological Polar Surface Area:104
Heavy Atom Count:12
Complexity:202
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
After entering the body, this product can combine with poisons containing hydroxyl or carboxyl groups to form low-toxic or non-toxic combinations that are excreted in the urine, protecting the liver and detoxifying. In addition, glucuronic acid can increase the content of liver glycogen and reduce fat reserves.
Registered Holders
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Beijing Jingfeng Pharmaceutical (Shandong) Co., Ltd.
Active
China
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Xuchang Future Pharmaceutical Co., Ltd.
Active
China
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Suzhou NO.5 Pharmaceutical FACTORY Co., Ltd.
Active
China
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