Fumes, silica
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Fumes, silica
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CAS No:
69012-64-2
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Chemical Name:
Fumes, silica
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Synonyms:
Fumes, silica;AMORPHOUS-FUMESILICA;AMORPHOUS SILICA FUME;Silica, amorphous - Fume total dust;Silica, amorphous - Fume, respirable;silica welding fumes;SILICAFUMES;Einecs 273-761-1
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CAS No:
Description
Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder
Produced by the volatilization and vaporization of furnace feed materials during the production of ferrosilicon and silicon metals. Consists primarily of silicon dioxide with carbon and trace elements.
An inhalation hazard. Much less toxic than crystalline forms. Does not cause silicosis. See also other silica entries
Amorphous fumed silica is used as a mineral, natural or synthetic fiber. A potential danger to those involved in the production and handling of fumed silica for paint pigments or catalysts. Diatomaceous earth is used in clarifying liquids, in manufacture of fire brick and heat insulators; used as a filtering agent; as a filler in construction materials; pesticides, paints, and varnishes. A potential danger to those involved in mining of diatomaceous earth or fabrication of products there from.
Sanitary landfill.
Safety Information
Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature.
Drug Information
Amorphous silica fume exposure is associated with recurrent fever, similar to metal fume fever, and nonprogressive pulmonary changes.More recently, the importance of silica fume particle size on toxicity has been noted.8 Specifically, particles of the ultrafine size range may be expected to have higher toxicity compared with particles of larger size.
Drug Function and Efficacy
Promotes macrophage phagocytosis, T lymphocyte proliferation and differentiation, and increases the activity of NK cells and interleukin-2 in tumor-bearing mice; improves appetite, body endurance, stress resistance and serum total protein levels in tumor-bearing mice; protects tumor-bearing mice from leukopenia and low cellular immunity caused by radiotherapy and chemotherapy, and reduces immune damage in mice caused by cyclophosphamide
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