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Kisspeptin 10 (human)

Kisspeptin 10 (human) structure

CAS No:
374675-21-5
Formula:
C63H83N17O14
Chemical Name:
Kisspeptin 10 (human)
Synonyms:
MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (112-121) (HUMAN);METASTIN (HUMAN, 45-54);METASTIN (45-54);METASTIN (45-54) AMIDE, HUMAN;METASTIN (45-54), HUMAN;KISSPEPTIN-13 (4-13) (HUMAN);KISS-1 GENE PRODUCT (HUMAN, 112-121 AMIDE);TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Kisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.

Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novelpeptideis mainly isolated from the human placenta.

Kisspeptin-10 Synthetic is a single, non-glycosylated polypeptide chain containing 10 amino acids, having a molecular mass of 1302 Dalton and a Molecular formula of C63H83N17O14 .

Kisspeptin 10 (human) Basic Attributes

Molecular Weight：

1302.44

Exact Mass：

1301.63054039

EC Number：

675-121-5

UNII：

FS1N52VS3S

Color/Form：

White to off-white

Characteristics

Density：

1.46±0.1 g/cm3(Predicted)

Water Solubility：

Soluble in water at 1mg/ml

PKA：

9.96±0.15(Predicted)

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

Storage features：

Store at -20°C

Drug Information

MeSH Entry Terms：

KiSS-1 metastasis-suppressor protein, human

Kisspeptin 10 (human) Use and Manufacturing

Kisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.

Kisspeptin-10 (human), a member of the kisspeptin family, is a neuropeptide that regulates gonadotropin secretion. It has anti-angiogenic effects, a concentration-dependent inhibition of HUVEC proliferation and migration, and is highly expressed in the placenta, which may help to regulate angiogenesis in this tissue. Kisspeptin-10 (human) is currently undergoing clinical studies with insulin secretion in men. It is also a potential drug target for the treatment of infertility.

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