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GLP-1

GLP-1 structure

CAS No:
87805-34-3
Formula:
C186H275N51O59
Chemical Name:
GLP-1
Synonyms:
HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY- THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARGY-GLY;GLUCAGON-LIKE PEPTIDE I HUMAN;GLUCAGON-LIKE PEPTIDE-1, HUMAN;GLUCAGON-LIKE PEPTIDE I;GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN);GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT);GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT;GLP-1
Categories:
Biochemical Engineering > Enzymes and Coenzymes Drugs

Description

GLP-1 stimulates pancreatic β cells to secrete insulin as an incretin hormone. GLP-1 also has additional actions, including suppression of glucagon secretion, inhibition of gastric motility, and promotion of satiety.

GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.

Glucagon-Like Peptide I (GLP1) is an incretin hormone, which functions as ligand for GLP1 receptors (GLP1R). These receptors are expressed in renal and cardiovascular system, such as smooth muscle and endothelial cells.

Glucagon Like Peptide-1 is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecular mass of 3297.7 Dalton.The GLP-1 is purified by proprietary chromatographic techniques.

GLP-1 Basic Attributes

Molecular Weight：

4169.48

EC Number：

201-258-5

HScode：

3504009000

Characteristics

Water Solubility：

Soluble to 5 mg/ml in water

Critical Temperature & Pressure：

−20°C

Safety Information

wgk germany：

Storage features：

Store at -20°C

GLP-1 Use and Manufacturing

Glucagon-Like Peptide I (GLP1) has been used as an antigen in excess amounts for the incubation of primary antibodies, post-immunocytochemistry with positive results of paraffin-embedded pancreatic tissues ofRana temporaria.

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