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Aripiprazole Lauroxil

Aripiprazole Lauroxil structure

CAS No:
1259305-29-7
Formula:
C36H51Cl2N3O4
Chemical Name:
Aripiprazole Lauroxil
Synonyms:
1259305-29-7.;Aripiprazole Lauroxil;Dodecanoic acid [7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2-oxo-1(2H)-quinolinyl]methyl ester;RDC 3317;schizophrenia,Aristada,inhibit,Aripiprazole Lauroxil,Inhibitor;(7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl dodecanoate;Pantoprazole Impurity 27 Hydrochloride;Aripiprazole Lauroxil, 10 mM in DMSO
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Aripiprazole lauroxil is a long acting injectable (LAI) pro-drug formulation of aripiprazole approved in the U.S. for the treatment of schizophrenia. Aripiprazole lauroxil is a dopamine D2 receptor partial antagonist, a 5-HT2A antagonist, and a 5- HT1A partial agonist that was developed by Alkermes. It was Aripiprazole lauroxil is a long acting injectable (LAI) pro-drug formulation of aripiprazole approved in the U.S. for the treatment of schizophrenia.28 Aripiprazole lauroxil is a dopamine D2 receptor partial antagonist, a 5-HT2A antagonist, and a 5- HT1A partial agonist that was developed by Alkermes. It was

ChEBI: A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripipraz le, it is used for treatment of schizophrenia.

Aripiprazole Lauroxil Basic Attributes

Molecular Weight：

660.71

Exact Mass：

660.71

EC Number：

826-270-7

Color/Form：

White to Off-White

Characteristics

Density：

1.153±0.06 g/cm3(Predicted)

Melting Point：

83 - 84°C

Boiling Point：

781.7±60.0 °C(Predicted)

PKA：

7.67±0.10(Predicted)

Critical Temperature & Pressure：

Refrigerator, under inert atmosphere

Aripiprazole Lauroxil Use and Manufacturing

Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.

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