 Home > Encyclopedia > (S)-3-Hydroxypyrrolidine

(S)-3-Hydroxypyrrolidine

(S)-3-Hydroxypyrrolidine structure

CAS No:
100243-39-8
Formula:
C4H9NO
Chemical Name:
(S)-3-Hydroxypyrrolidine
Synonyms:
(S)-3-PYRROLIDINOL (S)-3-HYDROXYPYRROLIDINE;(S)-(-)-3-PYRROLIDINOL;(S)-3-PYRROLIDINOL;(S)-3-Hydroxypyrrolidine ((S)-3-Pyrrolidinol);(S)-3-HYDROXYPYROLIDINE HYDROCHLORIDE;(S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99+%;(S)-3-Pyrrolidinol,99%e.e.;(S)-3-Pyrrolidinol >=97.0% (sum of enantiomers, GC)
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.

clear light yellow to yellow liquid after melting

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(S)-3-Hydroxypyrrolidine Basic Attributes

Molecular Weight：

87.12

Exact Mass：

87.12

BRN：

4652606

EC Number：

600-044-6

Color/Form：

Clear light yellow to yellow

HScode：

29339900

Characteristics

Density：

1.078 g/mL at 20 °C (lit.)

Melting Point：

15°C

Boiling Point：

108-110 °C (8 mmHg)

Refractive Index：

n20/D1.490

Water Solubility：

Fully miscible in water.

PKA：

14.91±0.20(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

Xi,Xn

safety instructions：

26-37/39-36-22

Hazard Statements：

36/37/38-40

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(S)-3-Hydroxypyrrolidine Use and Manufacturing

(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Recommended Suppliers of (S)-3-Hydroxypyrrolidine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

(S)-3-Hydroxypyrrolidine

CAS No.: 100243-39-8

Content: 99.00%

Inquiry
Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

(S)-pyrrolidin-3-ol 100243-39-8

CAS No.: 100243-39-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hunan Huateng Pharmaceutical Co. Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,peg derivatives,pharma intermediates

(S)-3-Hydroxypyrrolidine

CAS No.: 100243-39-8

Inquiry
Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

High quality (S)-3-Hydroxypyrrolidine CAS NO.100243-39-8

CAS No.: 100243-39-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry