Lipoxin A4
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Lipoxin A4
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CAS No:
89663-86-5
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Formula:
C20H32O5
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Chemical Name:
Lipoxin A4
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Synonyms:
7,9,11,13-Eicosatetraenoic acid,5,6,15-trihydroxy-,(5S,6R,7E,9E,11Z,13E,15S)-;7,9,11,13-Eicosatetraenoic acid,5,6,15-trihydroxy-,[5S-(5R*,6S*,7E,9E,11Z,13E,15R*)]-;(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-Trihydroxy-7,9,11,13-eicosatetraenoic acid;Lipoxin A;LXA;Lipoxin A4;5S,6R,15S-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid;LXA4;94292-81-6
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CAS No:
Lipoxin A4 Use and Manufacturing
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion. Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.
Computed Properties
Molecular Weight:352.5
XLogP3:3.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:14
Exact Mass:352.22497412
Monoisotopic Mass:352.22497412
Topological Polar Surface Area:98
Heavy Atom Count:25
Complexity:451
Undefined Atom Stereocenter Count:3
Undefined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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