Letaxaban
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Letaxaban
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CAS No:
870262-90-1
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Formula:
C22H26ClN3O5S
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Chemical Name:
Letaxaban
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Synonyms:
2(1H)-PyriMidinone, 1-[1-[(2S)-3-[(6-chloro-2-naphthalenyl)sulfonyl]-2-hydroxy-1-oxopropyl]-4-piperidinyl]tetrahydro;Letaxaban (TAK-442);1-[(2S)-3-[(6-Chloro-2-naphthalenyl)sulfonyl]-2-hydroxy-1-oxopropyl]-4-(tetrahydro-2-oxo-1(2H)-pyriMidinyl)piperidine;1-[1-[(2S)-3-[(6-chloro-2-naphthalenyl)sulfonyl]-2-hydroxy-1-oxopropyl]-4-piperidinyl]tetrahydro-2(1H)-pyriMidinone;1-[1-[(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl]piperidin-4-yl]tetrahydropyriMidin-2(1H)-one;TAK 442;Letaxaban;TAK 442;TAK442
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CAS No:
Description
Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.|Letaxaban is an orally active, tetrahydropyrimidin-2(1H)-one derivative and inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Letaxaban does not affect bleeding time.
Characteristics
118.89000
2.63070
1.415±0.06 g/cm3
173-174 °C(Solv: ethyl acetate (141-78-6))
824.5±65.0 °C(Predicted)
12.22±0.20
Drug Information
Endogenous factors and drugs that inhibit or block the activity of FACTOR XA. (See all compounds classified as Factor Xa Inhibitors.)
1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one
Letaxaban Use and Manufacturing
A potent and selective orally active factor Xa (FXa) inhibitor; anticoagulant. Effective in preventing venous thromboembolism in patient undergoing orthopedic surgery.
Computed Properties
Molecular Weight:480.0
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:479.1281698
Monoisotopic Mass:479.1281698
Topological Polar Surface Area:115
Heavy Atom Count:32
Complexity:796
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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