Tesetaxel
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Tesetaxel
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CAS No:
333754-36-2
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Formula:
C46H60FN3O13
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Chemical Name:
Tesetaxel
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Synonyms:
2-Pyridinepropanoic acid,β-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-α-hydroxy-,(2aS,2bR,3S,4S,6S,8aR,10S,11aS,11bR,13aR)-2a-(acetyloxy)-3-(benzoyloxy)-10-[(dimethylamino)methyl]-2a,2b,3,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-4-hydroxy-7,11b,14,14-tetramethyl-4,8-methano-2H-oxeto[3′′,2′′:3′,4′]benzo[1′,2′:3,4]cyclodeca[1,2-d][1,3]dioxol-6-yl ester,(αR,βS)-;DJ 927;Tesetaxel
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CAS No:
Description
Tesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others.|Tesetaxel is a semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.
Computed Properties
Molecular Weight:882.0
XLogP3:3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:15
Exact Mass:881.41101714
Monoisotopic Mass:881.41101714
Topological Polar Surface Area:202
Heavy Atom Count:63
Complexity:1780
Defined Atom Stereocenter Count:12
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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