DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7)
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DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7)
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CAS No:
204318-14-9
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Formula:
C65H92N14O18S2
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Chemical Name:
DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7)
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CAS No:
Description
Edotreotide is a chelated octreotide derivative with somatostatin activity. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of octreotide and chelated via dodecanetetraacetic acid (DOTA). Like octreotide, this edotreotide binds to somatostatin receptors (SSTRs), especially type 2, present on the cell membrane of many types of neuroendocrine tumors. When labeled with nuclides, edotreotide conjugates could result in tissue specific cytotoxicity.
DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) Basic Attributes
1421.64000
1420.61554449 g/mol
U194AS08HZ
C2616
V09IX
Drug Information
This medicinal product is for diagnostic use only.After radiolabelling with gallium (68Ga) chloride solution, the solution of gallium (68Ga) edotreotide obtained is indicated for Positron Emission Tomography (PET) imaging of somatostatin receptor overexpression in adult patients with confirmed or suspected well-differentiated gastro-enteropancreatic neuroendocrine tumours (GEP-NET) for localizing primary tumours and their metastases.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)
(DOTA(0)-Phe(1)-Tyr(3))octreotide
DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) Use and Manufacturing
Human drugs -> Orphan -> SomaKit TOC -> EMA Drug Category|Diagnostic radiopharmaceuticals -> Human pharmacotherapeutic group
Computed Properties
Molecular Weight:1421.6
XLogP3:-7.2
Hydrogen Bond Donor Count:17
Hydrogen Bond Acceptor Count:25
Rotatable Bond Count:26
Exact Mass:1420.61554449
Monoisotopic Mass:1420.61554449
Topological Polar Surface Area:531
Heavy Atom Count:99
Complexity:2620
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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