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Home > Encyclopedia > Flavone-8-acetic acid

Flavone-8-acetic acid

Flavone-8-acetic acid structure

Flavone-8-acetic acid 

structure
  • CAS No:

    87626-55-9

  • Formula:

    C17H12O4

  • Chemical Name:

    Flavone-8-acetic acid

  • Synonyms:

    4H-1-Benzopyran-8-acetic acid,4-oxo-2-phenyl-;4-Oxo-2-phenyl-4H-1-benzopyran-8-acetic acid;NSC 347512;LM 975;Flavone-8-acetic acid;Mitoflaxone;Flavone acetic acid;2-(4-Oxo-2-phenyl-4H-chromen-8-yl)acetic acid

Description

Mitoflaxone is a synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation. (NCI04)

Flavone-8-acetic acid Basic Attributes

280.27500

280.27

X230G6E63B

347512

DTXSID50236534

C1101

2918300090

Characteristics

67.51000

3.08710

1.355g/cm3

234 °C @ Solvent: Ethanol

507.9ºC at 760 mmHg

192.8ºC

1.649

Water < 0.1 (mg/mL)|0.1 N NaOH ~20 (mg/mL)|0.1 N HCl < 0.1 (mg/mL)|0.1 M NaHCO3 < 0.3 (mg/mL)|95% EtOH 1 (mg/mL)|MeOH 1 (mg/mL)|CHCl3 < 0.1 (mg/mL)|DMSO > 100 (mg/mL)|TFA > 100 (mg/mL)|10% DMSO < 1 (mg/mL)

Safety Information

Bulk: As a bulk chemical, Flavone -8- acetic acid is stable for at least 3 months at 60 °C (HPLC). Solution: Solutions of 1 mg/mL dissolved in 0.1 N NaOH (pH 9) showed no decomposition for at least 27 hours.

Drug Information

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

flavone acetic acid

Computed Properties

Molecular Weight:280.27
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:280.07355886
Monoisotopic Mass:280.07355886
Topological Polar Surface Area:63.6
Heavy Atom Count:21
Complexity:448
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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