Flavone-8-acetic acid
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Flavone-8-acetic acid
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CAS No:
87626-55-9
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Formula:
C17H12O4
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Chemical Name:
Flavone-8-acetic acid
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Synonyms:
4H-1-Benzopyran-8-acetic acid,4-oxo-2-phenyl-;4-Oxo-2-phenyl-4H-1-benzopyran-8-acetic acid;NSC 347512;LM 975;Flavone-8-acetic acid;Mitoflaxone;Flavone acetic acid;2-(4-Oxo-2-phenyl-4H-chromen-8-yl)acetic acid
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CAS No:
Description
Mitoflaxone is a synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation. (NCI04)
Flavone-8-acetic acid Basic Attributes
280.27500
280.27
X230G6E63B
347512
DTXSID50236534
C1101
2918300090
Characteristics
67.51000
3.08710
1.355g/cm3
234 °C @ Solvent: Ethanol
507.9ºC at 760 mmHg
192.8ºC
1.649
Water < 0.1 (mg/mL)|0.1 N NaOH ~20 (mg/mL)|0.1 N HCl < 0.1 (mg/mL)|0.1 M NaHCO3 < 0.3 (mg/mL)|95% EtOH 1 (mg/mL)|MeOH 1 (mg/mL)|CHCl3 < 0.1 (mg/mL)|DMSO > 100 (mg/mL)|TFA > 100 (mg/mL)|10% DMSO < 1 (mg/mL)
Safety Information
Bulk: As a bulk chemical, Flavone -8- acetic acid is stable for at least 3 months at 60 °C (HPLC). Solution: Solutions of 1 mg/mL dissolved in 0.1 N NaOH (pH 9) showed no decomposition for at least 27 hours.
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
flavone acetic acid
Computed Properties
Molecular Weight:280.27
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:280.07355886
Monoisotopic Mass:280.07355886
Topological Polar Surface Area:63.6
Heavy Atom Count:21
Complexity:448
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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