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Robenacoxib

Robenacoxib structure

CAS No:
220991-32-2
Formula:
C16H13F4NO2
Chemical Name:
Robenacoxib
Synonyms:
Benzeneacetic acid,5-ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]-;5-Ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]benzeneacetic acid;CGS 34975;Robenacoxib;Onsior;2-(5-Ethyl-2-((2,3,5,6-tetrafluorophenyl)amino)phenyl)acetic acid
Categories:
Pharmaceutical Intermediates > Analgesics

Description

Robenacoxib is an aromatic amino acid that is 2-amino-5-ethylphenylacetic acid in which one of the amino hydrogens is replaced by a 2,3,5,6-tetrafluorophenyl group. A selective cyclooxygenase 2 inhibitor that is used in veterinary medicine for the relief of pain and inflammation in cats and dogs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic and a cyclooxygenase 2 inhibitor. It is an aromatic amino acid, a monocarboxylic acid, an organofluorine compound, a secondary amino compound and a member of phenylacetic acids.|Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.

Robenacoxib Basic Attributes

Molecular Weight：

327.27400

Exact Mass：

327.27

UNII：

Z588009C7C

DSSTox ID：

DTXSID90176607

ATC Code：

QM01AH91

Characteristics

PSA：

49.33000

XLogP3：

4.24910

Density：

1.407g/cm3

Boiling Point：

351ºC

Flash Point：

165.5ºC

Refractive Index：

1.569

Vapor Pressure：

1.69E-05mmHg at 25°C

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Cats (tablets):For the treatmentRelief of pain and inflammation associated with acute andor chronic musculo-skeletal disorders.For the reduction of moderate pain and inflammation associated with orthopaedic surgery.Dogs (tablets):For the Ttreatment of pain and inflammation associated with chronic osteoarthritis.For the treatment of pain and inflammation associated with soft tissue surgery.Cats and dogs (solution for injection):For the Ttreatment of pain and inflammation associated with orthopaedic or soft tissue surgery.

MeSH Entry Terms：

robenacoxib

Robenacoxib Use and Manufacturing

Use Classification：

Veterinary drugs -> Onsior -> EMA Drug Category|Anti-inflammatory and anti-rheumatic products, non-steroids, Coxibs -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:327.27
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:327.08824131
Monoisotopic Mass:327.08824131
Topological Polar Surface Area:49.3
Heavy Atom Count:23
Complexity:398
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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