(T-4)-Bis(N,N-dimethylcarbamodithioato-κS,κS′)lead

447 g/mol

447.96499 g/mol

242-748-2

1545

DTXSID6020775

White powder|Solid or pale-yellow needles from acetone|White to off-white powder

72.7 Ų

2.43 g/cm³

>310 °C

less than 0.1 mg/mL at 73° F (NTP, 1992)|Less than 0.1 mg/mL water at 73 °F (23 °C)|Insoluble in all common organic solvents; slightly soluble in cyclohexanone|Insoluble in toluene, <0.1 g solute/100 mL solution|In DMSO (dimethyl sulfoxide): 1-10 mg/mL at 20 °C|Solubility in water: none

... electrochemical behavior of metal dithiocarbamates, incl ledate, has been reported.|Melting pt: 300 °C minimum|Dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.|Dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Insoluble in water.

Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts

LEAD DIMETHYLDITHIOCARBAMATE is a organometallic with thio carbamate chelating group. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides. Organometallics are strongly reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.

OF8850000

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D008, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Chemical Treatability of Lead; Concentration Process: Biological Treatment; Chemical Classification: Metal; Scale of Study: Respirometer Study; Results of Study: Oxygen uptake inhibited. /Inorganic lead cmpd/|Chemical Treatability of Lead; Concentration Process: Biological Treatment; Chemical Classification: Metal; Scale of Study: Laboratory Scale; Type of Wastewater Used: Synthetic Wastewater; Results of Study: No stimulation or inhibition of biological growth (study of Nitrosomonas bacteria). /Inorganic lead cmpd/

Strong oxidizers, hydrogen peroxide, acids. /Lead/

DHHS/ATSDR; Toxicological Profile for Lead (August 2007).[Available from, as of May 3, 2016: http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf]|National Toxicology Program; Report on Carcinogens, Thirteenth Edition (2014). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Lead and Lead Compounds are listed as reasonably anticipated to be human carcinogens. /Lead and Lead Compounds/[Available from, as of May 3, 2016: http://ntp.niehs.nih.gov/pubhealth/roc/roc13/]|Nat'l Research Council Canada; Effects of Lead in the Canadian Environment (1978) NRCC No. 16736|USEPA; The Health and Environmental Impacts of Lead (1979) EPA 560/2-79-001|DHEW/NCI; Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (1979) Technical Rpt Series No. 151 DHEW Pub No. (NIH) 79-1707

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P281, P301+P312, P304+P312, P304+P340, P308+P313, P312, P314, P330, P405, and P501

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material at ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Workers who are exposed to lead in any of its forms should wear personal protective equipment (PPE), which should be washed or renewed regularly. Protective clothing made of certain man-made fibers retains much less dust than cotton overalls and should be used where the conditions of work render it possible; turn ups, pleats and pockets in which lead dust may collect should be avoided. /Lead/|Wear appropriate personal protective clothing to prevent skin contact. /Lead/|Wear appropriate eye protection to prevent eye contact. /Lead/|Respirator Recommendations: Up to 0.5 mg/cu m. /Lead/[Table#4261]|For more Personal Protective Equipment (PPE) (Complete) data for Lead Dimethyldithiocarbamate (10 total), please visit the HSDB record page.

Combustible when exposed to heat or flame.

Extinguishant: Dry sand, dry dolomite, or dry graphite. /Inorganic lead/|If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Lead compounds, NOS/

Lead is combustible in powder form when exposed to heat or flame. /Inorganic lead/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|The following wastewater treatment technologies have been investigated for lead: Concentration process: Biological treatment. /Lead/|The following wastewater treatment technologies have been investigated for lead: Concentration process: Chemical precipitation. /Lead/|The following wastewater treatment technologies have been investigated for lead: Concentration process: Reverse osmosis. /Lead/|For more Cleanup Methods (Complete) data for Lead Dimethyldithiocarbamate (16 total), please visit the HSDB record page.

Cloakroom accommodation should be provided for ... PPE, with separate accommodation for clothing taken off during working hours. Washing accommodation, including bathing accommodation with warm water, should be provided and used. Time should be allowed for washing before eating. Arrangements should be made to prohibit eating and smoking in the vicinity of lead processes and suitable messrooms should be provided. /Lead/|1) The employer shall ensure that all personal protective devices are inspected regularly and maintained in clean and satisfactory working condition. 2) Working clothing and shoes shall not be taken home by employees. The employer shall provide for maintenance and laundering of protective clothing. 3) The employer shall ensure that precautions necessary to protect laundry personnel are taken when soiled protective clothing is laundered. /Inorganic lead compounds/|OSHA has recommended engineering controls over administrative controls and protective equipment to reduce exposures to chemicals in the workplace. The application of employee training and motivation programs (such as job safety analysis) to reduce exposures to chemicals has not been emphasized. To determine the effectiveness of such programs, a pilot project in an alkyl lead production facility was conducted with 35 employees in an effort to reduce exposures to organic and inorganic lead. Results after 12 mo showed a 40% reduction in Pb in urine and a 24% reduction in Pb in blood, both indicators of total exposure to organic and inorganic Pb. /Inorganic and alkyl lead compounds/|Protective clothing shall be changed at least daily at the end of the shift and more frequently if it should become grossly contaminated. /Inorganic lead/|For more Preventive Measures (Complete) data for Lead Dimethyldithiocarbamate (19 total), please visit the HSDB record page.

NIOSH considers "Lead" to mean metallic lead, lead oxides, and lead salts (including organic salts such as lead soaps but excluding lead arsenate).|Recommended Exposure Limit: 10 hr Time-Weighted Avg: 0.050 mg/cu m /Lead/|Air concentrations should be maintained so that worker blood lead remains less than 0.06 mg Pb/100 g of whole blood. /Lead/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting.

Separated from food and feedstuffs.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance may have effects on the blood and kidneys. This may result in anaemia and kidney impairment.

NO open flames.

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

National primary and secondary ambient air quality standards for lead and its compounds, measured as elemental lead by a reference method based on appendix G to this part, or by an equivalent method, are: 1.5 ug/cu m, maximum arithmetic mean averaged over a calendar quarter. /Lead and its compounds, as Pb/|Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Lead compounds are included on this list. /Lead compounds/

D008; A solid waste containing lead may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Lead/

D008; A solid waste containing lead may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Lead/

IDENTIFICATION AND USE: Lead dimethyldithiocarbamate is a white powder. It is used in rubber processing industry as accelerator for high speed, high temp vulcanization. It is used in compounding natural, styrene-butadiene, isobutylene-isoprene, isoprene and butadiene rubbers. It is effective under continuous curing conditions and is generally used with thiazole modifiers. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: A bioassay of technical grade lead dimethyldithiocarbamate for possible carcinogenicity was conducted by administering the test chemical in feed to rats and mice. Groups of 50 rats of each sex and 50 mice of each sex were administered lead dimethyldithiocarbamate at one of the two doses, either 25 or 50 ppm, for 104 or 105 weeks. Matched controls consisted of 20 untreated rats and 20 untreated mice of each sex. It is concluded that under the conditions of this bioassay, lead dimethyldithiocarbamate was not carcinogenic for rats or mice of either sex.

LD50 Rat oral > 10 mL/kg

A bioassay of technical grade lead dimethyldithiocarbamate for possible carcinogenicity was conducted by administreing the test chemical in feed to F344 (Fischer) rats and B6C3F1 mice. Groups of 50 rats of each sex and 50 mice of each sex were administered lead dimethyldithioarbamate at one of the two doses, either 25 or 50 ppm, for 104 or 105 weeks. Matched controls consisted of 20 untreated rats and 20 untreated mice of each sex. All surviving animals were killed at the end of the period of adminisitration of the test chemical. Mean body weights of the dosed male rats and female mice were slightly lower than those of the corresponding controls; mean body weights of the dosed female rats and male mice were essentially the same as those of the corresponding controls. Survival rates in both species were unaffected by administration of the test chemical. The lack of toxicity in both species suggests that a maximum tolerated dose level may not have been used. Therefore, the studies may not have been conducted using maximum sensitivity for the assessment of the possible carcinogenicity of lead dimethyldithiocarbamate. No tumors occurred in the rats or mice of either sex at incidences that were significantly higher in the dosed groups than in control groups. It is concluded that under the conditions of this bioassay, lead dimethyldithiocarbamate was not carcinogenic for F344 rats or B6C3F1 mice of either sex.

Ledate (lead dimethyldithiocarbamate) is not known to occur as natural product.

AQUATIC FATE: Dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines(1); such decompositions are accelerated by acids(1). Sodium dimethyldithiocarbamate has measured hydrolysis half-lives of 0.62, 41.6 and 860.5 hours at respective pHs of 4, 7 and 9 at 25 °C(2). Therefore, lead dimethyldithiocarbamate is expected to be susceptible to hydrolysis under environmental conditions(SRC). Lead dimethyldithiocarbamate is reported to be non-bioaccumulative in fish(3).[(1) NOAA; CAMEO Chemicals. Database of Hazardous Materials. Lead Dimethyldithiocarbamate (19010-66-3). Natl Ocean Atmos Admin, Off Resp Rest; NOAA Ocean Serv. Available from, as of August 2, 2016: http://cameochemicals.noaa.gov/ (2) ECHA; Search for Chemicals. Sodium Dimethyldithiocarbamate (CAS 128-04-1) Registered Substances Dossier. European Chemical Agency; Available from, as of August 3, 2016: http://echa.europa.eu/ (3) ECCC; Results of DSL Categorization. Environment and Climate Change Canada. Available from, as of August 2, 2016|ATMOSPHERIC FATE: Lead dimethyldithiocarbamate has a melting point of 310 °C(1) which suggests the compound will exist solely in the particulate phase in the ambient atmosphere(SRC). Particulate-phase lead dimethyldithiocarbamate- will be removed from the air by wet and dry deposition(SRC).

Dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines(1); such decompositions are accelerated by acids(1). Sodium dimethyldithiocarbamate has measured hydrolysis half-lives of 0.62, 41.6 and 860.5 hours at respective pHs of 4, 7 and 9 at 25 °C(2). Therefore, lead dimethyldithiocarbamate is expected to be susceptible to hydrolysis under environmental conditions(SRC).

Lead dimethyldithiocarbamate is reported to be non-bioaccumulative in fish(1).[(1) ECCC; Results of DSL Categorization. Environment and Climate Change Canada. Available from, as of August 2, 2016

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,428 workers (80 of these are female) are potentially exposed to lead dimethyldithiocarbamate in the US(1). Occupational exposure to lead dimethyldithiocarbamate- may occur through inhalation and dermal contact with this compound at workplaces where lead dimethyldithiocarbamate is produced or used(SRC).

SYMPTOMS: Symptoms of exposure to a related compound include reddening and swelling of the eyes and skin, blisters, tearing, runny nose, dry throat and chest discomfort. Inhalation may cause sneezing and coughing. Other symptoms include irritation of the skin, eyes, mucous membranes and respirator tract. Exposure can cause conjunctivitis, erythema, rapid pulse, dizziness, urticaria, intolerance to alcohol, palpitation and hypotension. It may also cause vasodilation of the face and neck, tachycardia, tachypnea, cardiac arrhythmias, pallor, hypertension, convulsions, myocardial infarction, optic neuritis, peripheral neuropathy, hypersensitivity hepatitis, fatigue, sleepiness, headache, chromosomal aberrations (rare) and damage in the nerve cells of the cerebral cortex. Other symptoms include clinical and subclinical liver dysfunction and asthenia, thoracic pain, skin lesions, myocardial dystrophia and enlargement of the thyroid. It may cause reduced potency, gastrointestinal disorders, unpleasant taste, lowered blood pressure, mild confusion, lethargy, impaired memory span, bizarre behavior, emotional lability, ataxia, hallucinations, uncontrollable arm movements, irritability, speech difficulty, drowsiness, loss of libido, psychoses (rare), Parkinsonian tremor, neuropsychiatric effects, anorexia, weight loss, emesis, coma, delirium, catatonia, suppression of the tendon reflexes, hypotonia, flaccid paralysis and death. It may also cause hyperventilation, sweating, breathlessness, air hunger, chest pain, central nervous system depression and rash. Pulmonary damage may also occur. Diarrhea and allergic eczema have been reported. Photophobia and skin sensitization are also symptoms. Inhalation of a related compound after alcohol consumption has caused nausea, vomiting and flushing. It also causes collapse. Other symptoms following alcohol ingestion include gastric pain, hyperirritability, fine tremor of the fingers and tongue, elevated blood pressure, slight fever, moderate lymphopenia; albumin, urobilinogen and numerous casts in the urine, liver enlargement, ulcers of the oral cavity and goiters. Symptoms of exposure to this type of chemical may include abdominal pain or discomfort, colic, constipation, metallic taste, nausea, vomiting, lassitude, insomnia, weakness, joint and muscle pains, lead line on the gums, pyorrhea, abdominal tenderness, basophilic stippling, anemia, slight albuminuria and increased urinary excretion. Other symptoms of exposure to this type of chemical may include black stools, oliguria, collapse, apathy, loss of recently developed skills, nervousness, vague pains in the arms and legs, incoordination, sensory disturbances of the extremities, paralysis of extensor muscles of arms and legs with wrist and foot drop, disturbance of menstrual cycle, abortion, stupor, encephalopathy, papilledema and paralysis of the cranial nerves. Exposure may also cause nightmares, muscular weakness, restlessness, anxiety, hypothermia, bradycardia, delusions, exaggerated muscular movements and a maniacal state. It may also cause seizures and cardiorespiratory arrest. Chronic exposure may cause severe damage to blood-forming, nervous system, urinary and reproductive systems; excessive tiredness numbness, hyperactivity, damage to the central nervous system, feeling of dull ness, kidney disease, permanent kidney damage, birth defects, stillbirth and decreased hemoglobin. It causes decreased sex drive, impotence and sterility in men. In women, it may cause decreased fertility. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of lead, nitrogen oxides and sulfur oxides. Ingestion of alcoholic beverages can result in potentially serious toxic effects after exposure (including topical) of this type of compound. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Lead and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Lead and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Moderate hyperventilation (20 respirations per minute) may be beneficial for increased intracranial pressure. Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) TKO /SRP: "To keep open", minimal flow rate/. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Lead and related compounds/|Treatment: Emergency and supportive measures: Treat seizures and coma if they occur. Provide adequate fluids to maintain urine flow (optimally 1-2 mL/kg/hr) but avoid overhydration, which may aggravate cerebral edema. Avoid phenothiazines for delirium, as they may lower the seizure threshold. Patients with increased intracranial pressure may benefit from corticosteroids ... and mannitol ... .|For more Antidote and Emergency Treatment (Complete) data for Lead Dimethyldithiocarbamate (9 total), please visit the HSDB record page.

The substance can be absorbed into the body by inhalation and by ingestion.

ESSENTIALLY 100% AS ACCELERATOR FOR RUBBER VULCANIZATION

Ledate powder is avail commercially in the USA ... with ... particle size, 99% passes through 100 mesh screen; lead content, 45.5-47.5%; ... moisture (at 100-105 °C), 1% max. For rubber processing ... in the form of rods with similar specifications. ... Also available as paste with 30% light oil and as a dispersion with 25% polyisobutylene binder.

Lead, bis(N,N-dimethylcarbamodithioato-.kappa.S,.kappa.S')-, (T-4)-: ACTIVE|Commercial production in the USA was first reported in 1934.