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Home > Encyclopedia > 1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide

1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide

1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide structure

1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide 

structure
  • CAS No:

    99591-73-8

  • Formula:

    C3H6O6S2

  • Chemical Name:

    1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide

  • Synonyms:

    1,5,2,4-Dioxadithiepane,2,2,4,4-tetraoxide;Cyclic-SoSo;Cyclodisone;NSC 348948

Description

Cyclodisone is a cyclic sulfonate ester with potential antineoplastic activity. As an alkylating agent, clyclodisone induces the formation of DNA interstrand crosslinks, DNA strand breaks, and alkali-labile lesions in the DNA of some tumor cell lines. Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)

1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide Basic Attributes

202.2 g/mol

202.21

7YFV4WN79I

348948

DTXSID80244147

C28899

Characteristics

104 Ų

Water < 1 (mg/mL)|Acetate buffer, pH 4 < 1 (mg/mL)|Carbonate buffer, pH 9 < 1 (mg/mL)|0.1 N HCl < 1 (mg/mL)|0.1 N NaOH 10-13 (mg/mL)|Ethanol (95%) < 1 (mg/mL)|Acetone > 100 (mg/mL)|CH3CN > 100 (mg/mL)|CHCl3 < 1 (mg/mL)|DMSO > 100 (mg/mL)|DMF > 100 (mg/mL)

Safety Information

Bulk: Cyclodisone stored for 90 days at room temperature and at 50 °C under both dark and light conditions was stable (HPLC). Samples stored at 50 °C turned a light tan color. Solution: 180 mg of Cyclodisone was dissolved in 60 mL of DMSO/water (50/50, v/v). Aliquots of this solution (5 mL) were diluted to 10 mL with internal standard solution (5 mL, phenol 1.8 mg/mL in CH3CN/water, 20/80, v /v) and the concentration was determined over a 4 hour period using the HPLC system described below. The t90 was 320 min.

Drug Information

1,5,2,4-dioxadithiepane-2,2,4,4-tetraoxide

Computed Properties

Molecular Weight:202.2
XLogP3:-1.1
Hydrogen Bond Acceptor Count:6
Exact Mass:201.96058025
Monoisotopic Mass:201.96058025
Topological Polar Surface Area:104
Heavy Atom Count:11
Complexity:278
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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