1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide
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1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide
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CAS No:
99591-73-8
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Formula:
C3H6O6S2
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Chemical Name:
1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide
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Synonyms:
1,5,2,4-Dioxadithiepane,2,2,4,4-tetraoxide;Cyclic-SoSo;Cyclodisone;NSC 348948
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CAS No:
Description
Cyclodisone is a cyclic sulfonate ester with potential antineoplastic activity. As an alkylating agent, clyclodisone induces the formation of DNA interstrand crosslinks, DNA strand breaks, and alkali-labile lesions in the DNA of some tumor cell lines. Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)
1,5,2,4-Dioxadithiepane, 2,2,4,4-tetraoxide Basic Attributes
202.2 g/mol
202.21
7YFV4WN79I
348948
DTXSID80244147
C28899
Characteristics
104 Ų
Water < 1 (mg/mL)|Acetate buffer, pH 4 < 1 (mg/mL)|Carbonate buffer, pH 9 < 1 (mg/mL)|0.1 N HCl < 1 (mg/mL)|0.1 N NaOH 10-13 (mg/mL)|Ethanol (95%) < 1 (mg/mL)|Acetone > 100 (mg/mL)|CH3CN > 100 (mg/mL)|CHCl3 < 1 (mg/mL)|DMSO > 100 (mg/mL)|DMF > 100 (mg/mL)
Safety Information
Bulk: Cyclodisone stored for 90 days at room temperature and at 50 °C under both dark and light conditions was stable (HPLC). Samples stored at 50 °C turned a light tan color. Solution: 180 mg of Cyclodisone was dissolved in 60 mL of DMSO/water (50/50, v/v). Aliquots of this solution (5 mL) were diluted to 10 mL with internal standard solution (5 mL, phenol 1.8 mg/mL in CH3CN/water, 20/80, v /v) and the concentration was determined over a 4 hour period using the HPLC system described below. The t90 was 320 min.
Computed Properties
Molecular Weight:202.2
XLogP3:-1.1
Hydrogen Bond Acceptor Count:6
Exact Mass:201.96058025
Monoisotopic Mass:201.96058025
Topological Polar Surface Area:104
Heavy Atom Count:11
Complexity:278
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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1,3-dioxa-2λ6,4λ6-dimolybdacyclobutane 2,2,4,4-tetraoxide
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3-methyl-1,5,2,4-dioxadithiepane 2,2,4,4-tetraoxide Formula
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1,5,2,4-Dioxadithiane, 2,2,4,4-tetraoxide Formula
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