Trimethoprim sulfate
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Trimethoprim sulfate
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CAS No:
56585-33-2
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Formula:
C14H18N4O3.1/2H2O4S
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Chemical Name:
Trimethoprim sulfate
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Synonyms:
2,4-Pyrimidinediamine,5-[(3,4,5-trimethoxyphenyl)methyl]-,sulfate (2:1);Trimethoprim hemisulfate;Trimethoprim sulfate
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CAS No:
Description
Trimethoprim Sulfate is the sulfate salt form of trimethoprim, a synthetic substituted pyrimidine with antibacterial activity. Trimethoprim sulfate selectively binds to and reversibly inhibits dihydrofolate reductase, thereby blocking the production of tetrahydrofolic acid from dihydrofolic acid. This leads to an inhibition of bacterial synthesis of folic acid, thereby affecting nucleic acid and protein synthesis. Trimethoprim sulfate has a stronger binding affinity for the bacterial enzyme than for the corresponding mammalian enzyme.
Trimethoprim sulfate Basic Attributes
678.7 g/mol
678.24316061 g/mol
E377MF8EQ8
DTXSID40205138
C48028
Trimethoprim sulfate Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:678.7
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:10
Exact Mass:678.24316061
Monoisotopic Mass:678.24316061
Topological Polar Surface Area:294
Heavy Atom Count:47
Complexity:388
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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