Mitindomide
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Mitindomide
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CAS No:
10403-51-7
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Formula:
C14H12N2O4
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Chemical Name:
Mitindomide
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Synonyms:
4,8-Ethenopyrrolo[3′,4′:3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H,6H)-tetrone,3a,3b,4,4a,7a,8,8a,8b-octahydro-,(3aR,3bS,4R,4aR,7aS,8S,8aR,8bS)-rel-;Tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxylic 3,4:7,8-diimide;4,8-Ethenopyrrolo[3′,4′:3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H,6H)-tetrone,3a,3b,4,4a,7a,8,8a,8b-octahydro-,(3aα,3bβ,4α,4aβ,7aβ,8α,8aβ,8bα)-;rel-(3aR,3bS,4R,4aR,7aS,8S,8aR,8bS)-3a,3b,4,4a,7a,8,8a,8b-Octahydro-4,8-ethenopyrrolo[3′,4′:3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H,6H)-tetrone;Benzenebismaleimide adduct;Mitindomide;NSC 284356;93922-82-8
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CAS No:
Description
Mitindomide is a bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis. This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04)
Characteristics
92.3 Ų
p- dioxane slightly soluble (mg/mL)|Aqueous NaOH (2 moles NaOH per mole of compound) > 20 (mg/mL)
Safety Information
Solution: A solution was prepared by dissolving 100 mg of drug in 3.0 mL of 0.25 N NaOH. This solution was diluted to 5.0 mL with water to give a final concentration of 20 mg/mL. At room temperature this solution shows 10% decomposition in 40 minutes and 50% decomposition in 5 hours (HPLC).
Drug Information
3a,3b,4,4a,7a,8a,8b-octahydro-4,8-ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone
Computed Properties
Molecular Weight:272.26
XLogP3:-1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Exact Mass:272.07970687
Monoisotopic Mass:272.07970687
Topological Polar Surface Area:92.3
Heavy Atom Count:20
Complexity:587
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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