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Exatecan

Exatecan structure

CAS No:
171335-80-1
Formula:
C24H22FN3O4
Chemical Name:
Exatecan
Synonyms:
10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione,1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-,(1S,9S)-;10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione,1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-,(1S-trans)-;(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione;DX 8951;Exatecan;(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-1-amine
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Exatecan is a pyranoindolizinoquinoline.|Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.

Exatecan Basic Attributes

Molecular Weight：

435.4 g/mol

Exact Mass：

435.45

UNII：

OC71PP0F89

DSSTox ID：

DTXSID60169061

Characteristics

PSA：

106 Å²

Drug Information

MeSH：

Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)

MeSH Entry Terms：

(1S,9S)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)dione methanesulfonate

Computed Properties

Molecular Weight:435.4
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:435.15943435
Monoisotopic Mass:435.15943435
Topological Polar Surface Area:106
Heavy Atom Count:32
Complexity:950
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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