 Home > Encyclopedia > (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride structure

CAS No:
195733-43-8
Formula:
C29H39ClN2O6
Chemical Name:
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride
Synonyms:
(11C)ABT-627;2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(((dibutylamino)carbonyl)methyl)pyrrolidine-3-carboxylic acid;A 127722;A 127722.5;A 147627;A-127722;A-127722.5;A-147627;A127722;A127722.5;A147627;ABT 627;ABT-627;ABT627;atrasentan;Atrasentan Hydrochloride;Xinlay;Atrasentan hydrochloride;195733-43-8;Atrasentan HCl;Atrasentan (hydrochloride);UNII-E4G31X93ZA;Atrasentan hydrochloride [USAN];E4G31X93ZA;195733-43-8 (HCl);ABBOT-147627;3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-;A-147627.1;Atrasentan hydrochloride (USAN);Abbott 147627;(2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride;(2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride.;3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-;A 147627.1;D03009;CHEMBL2106068;DTXSID20173240;EX-A4175;HY-15403A;MFCD13194884;CS-1373;BS-16407;Atrasentan hydrochloride, >=98% (HPLC);A3201;W-5571;733A438;ABT-627;ABT627;ABT 627;Abbott 147627;Q27276859;(2r,3r,4s)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(n,n-di(n-butyl)aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid hydrochloride salt;(2R,3R,4S)-1-((Dibutylcarbamoyl)methyl)-2-(p-methoxyphenyl)-4-(3,4-(methylenedioxy)phenyl)-3-pyrrolidinecarboxylic acid, monohydrochloride;3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R-(2alpha,3beta,4alpha))

Request for Quotation

Description

Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.|A pyrrolidine and benzodioxole derivative that acts a RECEPTOR, ENDOTHELIN A antagonist. It has therapeutic potential as an antineoplastic agent and for the treatment of DIABETIC NEPHROPATHIES.

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride Basic Attributes

Molecular Weight：

547.1 g/mol

Exact Mass：

546.2496647 g/mol

UNII：

E4G31X93ZA

DSSTox ID：

DTXSID20173240

NCI Thesaurus Code：

C1779

Characteristics

PSA：

88.5 Å²

Drug Information

Drug Indication：

Treatment of nephropathy

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN A RECECPTORS. (See all compounds classified as Endothelin A Receptor Antagonists.)

MeSH Entry Terms：

(11C)ABT-627

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride Use and Manufacturing

Use Classification：

Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:547.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:546.2496647
Monoisotopic Mass:546.2496647
Topological Polar Surface Area:88.5
Heavy Atom Count:38
Complexity:734
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Atrasentan hydrochloride

CAS No.: 195733-43-8

Content: 99.00%

Inquiry

Learn More Other Chemicals

3-(1-Ethyl-1H-benzoimidazol-2-yl)-propionic acidhydrochloride

1185297-90-8
3-(2-Dimethylamino-ethoxy)-benzoic acidhydrochloride

215315-99-4
4-AMINO-3-(4-METHOXY-PHENYL)-BUTYRIC ACIDHYDROCHLORIDE

432049-65-5
4-Aminomethyl-5-propyl-furan-2-carboxylic acidhydrochloride Formula

1052514-48-3
5-AMINOMETHYL-FURAN-3-CARBOXYLIC ACIDHYDROCHLORIDE Formula

944467-90-7
4-Dimethylaminopyridine-2-carboxylic acidhydrochloride Formula

1176419-71-8
4-(5-CHLORO-1H-BENZOIMIDAZOL-2-YL)-BUTYRIC ACIDHYDROCHLORIDE Structure

1185293-58-6
4-(2-AMINO-ETHOXY)-BENZOIC ACIDHYDROCHLORIDE Structure

1050208-10-0
What is 2-(2-Dimethylamino-ethoxy)-benzoic acidhydrochloride

1177320-86-3
What is 3-Dimethylaminomethyl-4-methoxy-benzoic acidhydrochloride

1185303-02-9

Hot Searches: k3po4; disodium pyrophosphate; benzoic acid sds; 1 3 bisphosphoglycerate; methyl acrylate; caprylic acid benefits

Guide of (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;hydrochloride

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.