Tonapofylline
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Tonapofylline
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CAS No:
340021-17-2
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Formula:
C22H32N4O4
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Chemical Name:
Tonapofylline
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Synonyms:
Bicyclo[2.2.2]octane-1-propanoic acid,4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-;4-(2,3,6,7-Tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)bicyclo[2.2.2]octane-1-propanoic acid;BG 9928;Tonapofylline
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CAS No:
Description
Tonapofylline is an oxopurine.|Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
Drug Information
Stimulation of A1 adenosine receptors in the kidney reduces glomerular filtration rate (GFR) via tubuloglomerular feedback and increases sodium reabsorption. Blocking A1 adenosine receptors would therefore maintain GFR and cause natriuresis. Tonapofylline is a xanthine derivative that binds with high affinity to A1 adenosine receptors from several species including human and acts as a competitive antagonist at these receptors.
3-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo(2.2.2)oct-1-yl)propionic acid
Computed Properties
Molecular Weight:416.5
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:416.24235551
Monoisotopic Mass:416.24235551
Topological Polar Surface Area:107
Heavy Atom Count:30
Complexity:687
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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