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imidazenil

imidazenil structure

CAS No:
151271-08-8
Formula:
C18H12BrFN4O
Chemical Name:
imidazenil
Synonyms:
imidazenil;6-(2-Bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide,6-(2-bromophenyl)-8-fluoro-;9-(2-bromophenyl)-12-fluoro-2,4,8-triazatricyclo[8.4.0.02,?]tetradeca-1(14),3,5,8,10,12-hexaene-5-carboxamide;Imidazenil, 10 mM in DMSO
Categories:
Pharmaceutical Intermediates > Antibacterials

Description

Imidazenil is an imidazobenzodiazepine with the profile of a partial agonist. Animal studies have shown that it does not produce sedation or ataxia in rats nor does it potentiate the effects of alcohol (Guisti et al. 1993). Imidazenil has a low intrinsic activity at the GABAA receptor and therefore causes only slight enhancement of GABA-ergic tone. Its efficacy may, however, be increased when GABA tone is reduced, which could lead to its being active only in conditions where GABA tone is altered. This may well make it an ideal treatment for anxiety and epilepsy.

imidazenil Basic Attributes

Molecular Weight：

399.22

Exact Mass：

399.22

EC Number：

202-303-5

UNII：

7N95V6864R

DSSTox ID：

DTXSID90164746

Color/Form：

White to off-white

Characteristics

Density：

1.67±0.1 g/cm3(Predicted)

Boiling Point：

587.0±50.0 °C(Predicted)

PKA：

15.37±0.40(Predicted)

Drug Information

MeSH：

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

MeSH Entry Terms：

6-(2-bromophenyl)-8-fluoro-4-H-imidazo(1,5-a)(1-4)benzodiazepine-3-carboxamide

imidazenil Use and Manufacturing

Imidazenil, a new anxiolytic and anticonvulsant drug, attenuates a benzodiazepine-induced cognition deficit in monkeys.

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