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Gadobutrol

Gadobutrol structure

CAS No:
138071-82-6
Formula:
C18H31N4O9.Gd
Chemical Name:
Gadobutrol
Synonyms:
Gadobutrol;GadoliniuM,[10-[2,3-dihydroxy-1-(hydroxyMethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-kN1,kN4,kN7,kN10,kO1,kO4,kO7]-;gallium 10-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate;CL124;gadolinium(III) 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate;CS-113;gudobutrol;Ggadobutrol
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framework and is neutral. It is a water-soluble, highly hydrophilic compound with a partition coefficient between n-butanol and buffer at pH 7.6 of ~ 0.006.

Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Gadobutrol Basic Attributes

Molecular Weight：

604.712

Exact Mass：

516.13468

EC Number：

1308068-626-2

Color/Form：

White to Off-White

Characteristics

Density：

1.3 g/mL at 37 °C

Melting Point：

>264°C (dec.)

Toxicity：

LD50 i.v. in mice: 23 mmol/kg (Vogler)

PH：

6.6-8

Critical Temperature & Pressure：

Refrigerator

Gadobutrol Use and Manufacturing

Gadobutrol is a gadolinium-based MRI contrast agent (GBCA).

Gadobutrol injection is a magnetic resonance imaging (MRI) contrast agent that is used to help create a clear picture of the body during an MRI scan. MRI scans are a special kind of procedure that lets a doctor look at the inside of the body, such as the brain.

Drug Function and Efficacy

Contrast agents

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Gadobutrol Injection
Specifications	15 ml: 9.0708 g

Gadobutrol Injection
Specifications	15ml:9.0708g

Gadobutrol Injection
Specifications	15ml:9.0708g

See More Related Drugs

Registered Holders

VIWIT PHARMACEUTICAL CO LTD

United States
Active
Bayer Ag

Finland
Active
Weinan Ruilian Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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