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DISUCCINIMIDYL SUBERATE

DISUCCINIMIDYL SUBERATE structure

CAS No:
68528-80-3
Formula:
C16H20N2O8
Chemical Name:
DISUCCINIMIDYL SUBERATE
Synonyms:
SUBERIC ACID BIS(N-HYDROXY-SUCCINIMIDE ESTER);DSS Crosslinker;Di(N-succinimidyl) Suberate;DISUCCINIMIDYL OCTANEDIOATE;DISUCCINIMIDYL SUBERATE;DSS;n-hydroxysuccinimidesubericacidester;Bis-(N-succinimidyl)-suberate
Categories:
Food Additives > Other Food Additives

Description

DSS Crosslinker is a membrane permeable, noncleavable crosslinker. The NHS ester groups are reactive toward primary amines.

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

DISUCCINIMIDYL SUBERATE Basic Attributes

Molecular Weight：

368.34

Exact Mass：

368.34

EC Number：

614-576-1

NSC Number：

340008

Color/Form：

White to Almost white

HScode：

29171900

Characteristics

Density：

1.295 g/cm3

Melting Point：

169-170°C

Boiling Point：

513.5±60.0 °C(Predicted)

Water Solubility：

Insoluble in water. Soluble in chloroform: 50 mg/mL.

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

safety instructions：

24/25

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

1,1'-((1,8-dioxo-1,8-octanediyl)bis(oxy))bis-2,5-pyrrolidinedione

DISUCCINIMIDYL SUBERATE Use and Manufacturing

Uses

Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.

Disuccinimidyl suberate is a homobifunctional amine-reactive crosslinker. It is usually coupled to molecules containing primary amines via amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates an 8-atom spacer arm.

Suberic acid bis(N-hydroxysuccinimide ester) has been:supplemented in pierce lysis buffer used for immunoprecipitationused to conjugate the oligonucleotide standards to gelatinused in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

Manufacturing Info：

Amides, rice bran-oil, N-[2-[(2-hydroxyethyl)amino]ethyl], acetates (salts): INACTIVE

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Disuccinimidyl suberate

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