Ceramide AP
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Ceramide AP
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CAS No:
212070-45-6
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Formula:
C36H73NO5
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Chemical Name:
Ceramide AP
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Synonyms:
Octadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy-;Ceramide AP;Water soluble Ceramide VI;ViableCare Ceramide AP;Sphingomyelin Impurity 8 (Ceramide VI);Octadecanamide,?N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy- Octadecanamide,?N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy-;2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide;Sphingomyelin Impurity 10
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CAS No:
Description
Ceramide AP (CER [AP]; AP stands for α-hydroxy-N-stearoylphytosphingosine) belongs to a larger group of ceramides that are naturally occurring, long chains of lipids (fats) in the skin. To put it into perspective, the skin’s general composition of ceramides is around 50%; of that, 16% of those ceramides are of the AP variety. CERs are sphingolipids that contain a sphingoid moiety (which can be sphingosine (S), dihydrosphingosine (D), phytosphingosine (P) or 6-hydroxy-sphingosine (H)), linked with a long-chain FFA moiety (which can be nonhydroxy (N), α-hydroxy (A) or ester-linked ω-hydroxy (EO)) through an amide bond. Research indicated that CER [AP], with four hydroxyl groups on its head group, can form super stable membranes through strong hydrogen bonds. It has also been shown to be antiproliferative and proapoptotic in numerous cancer cell types in vitro. Therefore, administration of CER [AP] to the skin might help to restore the barrier function of aged and affected skin[1–2].
ChEBI: N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine is a phytoceramide in which the ceramide N-acyl group is specified as 2-hydroxyoctadecanoyl
Ceramide AP Use and Manufacturing
Ceramide AP is a synthetic lipid component whose structure mimics that of ceramides naturally present in the stratum corneum of the skin. Therefore, it is used as an effective antioxidant and moisturizer in cosmetics and skincare products.
Drug Function and Efficacy
Supports skin's natural barrier, aids in cell renewal and hydration
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