Difluoromethyl phenyl sulfone
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Difluoromethyl phenyl sulfone
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CAS No:
1535-65-5
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Formula:
C7H6F2O2S
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Chemical Name:
Difluoromethyl phenyl sulfone
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Synonyms:
[(Difluoromethyl)sulfonyl]benzene;Difluoromethyl phenyl sulfone;1-(difluoroMethylsulfonyl)benzene;Benzene, [(difluoroMethyl)sulfonyl]-;PhSO2CF2H;Phenyl difluoromethyl sulfone;Difluoromethyl phenyl sulfone >=97%;Difluoromethyl Phenyl Sulfone >
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CAS No:
Description
Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.
light yellow liquid
Difluoromethyl phenyl sulfone Basic Attributes
192.18
192.00565693
2259218
No
DTXSID60473498
colorless
29309090
Characteristics
1.348
24-25℃
115-120 °C(Press: 7 Torr)
1.5000
Soluble in chloroform and water.
under inert gas (nitrogen or Argon) at 2–8 °C
Safety Information
3
Xi
26-24/25
36/38
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Difluoromethyl phenyl sulfone Use and Manufacturing
Efficient reagent for difluoromethylation of carbonyls and aldehydes.
Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls
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