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ALC-0315

ALC-0315 structure

CAS No:
2036272-55-4
Formula:
C48H95NO5
Chemical Name:
ALC-0315
Synonyms:
Decanoic acid, 2-hexyl-, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester;((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate);Decanoic acid, 2-hexyl-, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester ISO 9001：2015 REACH;6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate;Lipid ALC-0315;((4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate)(ALC-0315);ALC0315,ALC 0315;6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ALC-0315 ([(4-hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)) is a synthetic lipid. A colorless oily material, it has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo.

ALC-0315 Basic Attributes

Molecular Weight：

766.27

Exact Mass：

765.72102513

Color/Form：

Colorless to light yellow

Characteristics

Density：

0.919±0.06 g/cm3(Predicted)

Boiling Point：

760.6±55.0 °C(Predicted)

PKA：

15.11±0.10(Predicted)

Critical Temperature & Pressure：

2-8°C, protect from light

Safety Information

wgk germany：

WGK 3

Drug Information

MeSH Entry Terms：

(4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)

ALC-0315 Use and Manufacturing

ALC-0315 is one of the components of the BNT162b2 vaccine (0.43 mg per dose). Its chemical properties as a tertiary amine mean that its cation can form an ionic bond to the messenger RNA which carries the genetic information for the SARS-CoV-2 spike protein formation in the human body. Importantly, once the lipid nanoparticle which encapsulates the mRNA has been absorbed into antigen-presenting cells (a process called receptor-mediated endocytosis) the more acidic environment within the endosome fully protonates the ALC-0315 as a result the nanoparticle releases its payload of mRNA.

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