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Orforglipron

Orforglipron structure

CAS No:
2212020-52-3
Formula:
C48H48F2N10O5
Chemical Name:
Orforglipron
Synonyms:
1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy...;LY3502970;GLP-1 receptor agonist 1 USP/EP/BP;Orforglipron;Orforglipron（LY3502970）;LY3502970 (Orforglipron);3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one;OWL 833
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Orforglipron (LY3502970) (GLP-1 receptor agonist 1) is GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.

Orforglipron is an oral, non-peptide, small-molecule glucagon-like peptide-1 receptor agonist developed by Eli Lilly and Company as a weight-loss drug. Currently, the drug is still in Phase III clinical trials and has not yet received approval from the U.S. Food and Drug Administration (FDA). Eli Lilly's CEO expects the FDA to approve its investigational oral weight-loss drug, orforglipron, by March 2026, and to submit an application for the treatment of type 2 diabetes by the end of 2026.

Orforglipron Basic Attributes

Molecular Weight：

882.97

EC Number：

278-636-5

Color/Form：

Off-white to light yellow

Characteristics

Density：

1.50±0.1 g/cm3(Predicted)

PKA：

7.33±0.20(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Orforglipron Use and Manufacturing

Orforglipron is a non-peptide oral glucagon-like peptide-1 receptor agonist (GLP-1RA) widely used in the management of type 2 diabetes mellitus (T2DM) and obesity. In T2DM patients, the drug reduces glycated haemoglobin (HbA1c) by up to 2.10%, facilitates weight loss of up to 10.1 kilograms, and reduces waist circumference by up to 8.7 centimetres. Studies in overweight or obese populations indicate weight loss of up to 13.0 kilograms. Adverse reactions include mild to moderate vomiting and nausea, particularly common following high-dose therapy or rapid dose escalation. Consequently, it should be used cautiously under medical supervision.

Glucagon-like peptide-1 (GLP-1) agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat type 2 diabetes mellitus and, in some cases, obesity.

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