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Resveratrol

Resveratrol structure

CAS No:
501-36-0
Formula:
C14H12O3
Chemical Name:
Resveratrol
Synonyms:
TRANS-3,5,4'-STILBENETRIOL;TRANS-1,2-(3,4',5-TRIHYDROXYDIPHENYL)ETHYLENE;RESVERATROL;RESVERATROLE;3,4',5'-TRIHYDROXY-TRANS-STILBENE;3,4',5-TRIHYDROXY-TRANS-STILBENE;5-[2-(4-HYDROXY-PHENYL)-VINYL]-BENZENE-1,3-DIOL;5-[(1E)-2-(4-HYDROXYPHENYL)ETHENYL]-1,3,BENZENEDIOL
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Off-White to Tan Powder

ChEBI:Resveratrol is a stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. It has a role as a phytoalexin, an antioxidant, a glioma-associated oncogene inhibitor and a geroprotector. It is a stilbenol, a polyphenol and a member of resorcinols.

Resveratrol, a non-flavonoid polyphenolic compound, is widely found in the skin of red grapes, nuts, berries,Polygonum cuspidatumroot, etc. It is reportedly known to exhibit pharmacological properties including anti-cancer, anti-inflammatory, antioxidant, neuroprotectant, anti-atherogenic property and reduces the synthesis of pro-atherosclerotic substances.

Resveratrol Basic Attributes

Molecular Weight：

228.24

EC Number：

610-504-8

Color/Form：

Off-white

HScode：

29072990

Characteristics

Density：

1.359±0.06 g/cm3(Predicted)

Melting Point：

253-255°C

Boiling Point：

449.1±14.0 °C(Predicted)

Water Solubility：

Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).

PKA：

9.22±0.10(Predicted)

Henrys Law Constant：

7.0×1010mol/(m3Pa) at 25℃, HSDB (2015)

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

26-39-37/39-36/37/39

RTECS Number：

CZ8987000

Storage features：

+4°C

Hazard Statements：

37/38-41-36/38-36-43-22

Resveratrol Use and Manufacturing

Resveratrol can prevent the oxidation of low density lipoprotein, and has the potential effect on preventing cardiovascular disease, cancer, antivirus and immune regulation. Its main role is antioxidant properties.Cardiovascular drugs. It can reduce hematic fat and prevent heart disease. It also has the effect on AIDS[4].Antioxidants and the activity in anti-inflammatory, antithrombotic, anti-cancer, anti-cancer, anti hyperlipidemia and antibacterial.Anti-aging, regulating blood lipid, cardiovascular protection, anti-hepatitis.Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

raw material for Tamiflu; Oseltamivir

Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.

Resveratrol is a natural antioxidant. It reduces blood viscosity, inhibits platelet aggregation and vasodilation, keeps blood flowing smoothly, and prevents the occurrence and development of cancer. It has the effect of preventing and treating atherosclerosis, coronary heart disease, ischemic heart disease and hyperlipidemia. It has tumor-inhibiting effects. Resveratrol also has estrogen-like effects and can be used to treat breast cancer and other diseases. It slows down aging and prevents cancer. Red grape skins, red wine and grape juice contain high concentrations of resveratrol. Studies have shown that as humans age, the integrity of chromosomes is disrupted. However, resveratrol activates proteins that can repair chromosomes, thus slowing down aging.Resveratrol is effective in preventing aging, in part due to its antioxidant properties, and is recommended for use in pre- or post-sun products. Resveratrol can cross the stratum corneum and be found in the dermis and epidermis. It has been shown to protect dermal collagen and may be effective in enhancing glycosaminoglycans, thereby improving tissue hydration. It has been shown to stimulate cell renewal in the skin and to help increase skin thickness. It has been shown to inhibit tyrosinase, which suggests it may be used to reduce hyperpigmentation.

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