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RMC6236

RMC6236 structure

CAS No:
2765081-21-6
Formula:
C44H58N8O5S
Chemical Name:
RMC6236
Synonyms:
RMC6236;(Z)-N-(11-ethyl-12-(2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)-2-methylcyclopropane-1-carboxamide;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide , RMC-6236;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide;RMC-6236 RASONMULTI;Cyclopropanecarboxamide, N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-, (1S,2S)-;"Cyclopropanecarboxamide, N-[(2R,14S,18S)-1-ethyl-18, 19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-2";(1S,2S)-N-((63S,4S,Z)-11-ethyl-12-(2-((S)-1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-py
Categories:
Chemical Reagents > Organic Reagents

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RMC6236 Basic Attributes

Molecular Weight：

811.05

Color/Form：

White to off-white

Characteristics

Density：

1.37±0.1 g/cm3(Predicted)

PKA：

14.56±0.40(Predicted)

RMC6236 Use and Manufacturing

RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors[1][2][3].

Recommended Suppliers of RMC6236

Suzhou Rongfu New - Material Co., Ltd. Contact Supplier

CN
YRS

Business licensed

Trader Supplier of Pharmaceutical intermediate

RF-RMC6236

Unit Price: $400 /G EXW

CAS No.: 2765081-21-6

Content: 99.8%

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Shanghai Jianqi Chemical Company Contact Supplier

CN
YRS

Business licensed

Trader Supplier of chemical raw materials

High Purity 99% RMC-6236 White Crystal Raw Powder CAS 2765081-21-6 Custom Fine Chemical Intermediate Factory Supply

Unit Price: nullnull /null null

CAS No.: 2765081-21-6

Grade: Industrial Grade

Content: 98%

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Guide of RMC6236

Basic Attributes
Characteristics
Use and Manufacturing
Recommended Suppliers
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