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Gamma oryzanol

Gamma oryzanol structure

CAS No:
11042-64-1
Formula:
C40H58O4
Chemical Name:
Gamma oryzanol
Synonyms:
GAMMA-ORYZANOL;.gamma.-Orizanol;gamma-orizanol;gamma-oz;gammariza;Major coMpounds: Cycloartenylferulate and 24-Methylen Cycloartanylferulate;Other coMpounds: CaMpesterylferulate, CaMpestanylferulate, β-Sitosterylferulate and Cycloartanylferulate;Gu Weisu
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Gamma oryzanol is a lipid fraction derived from rice-bran oil. Oryzanol was first isolated from rice-bran oil in the 1950s. Several lipid fractions were isolated from the oil.The third (gamma) fraction isolated was oryzanol.It is made up of a mixture of ferulic acid esters and plant sterols. Similar in structure to cholesterol, the phytosterols and triterpenes that comprise oryzanol include campesterol, stigmasterol, beta sitosterol, cycloartanol, and cycloartenol. Because phytosterols are poorly absorbed, it has been suggested that they may reduce blood cholesterol by inhibiting intestinal cholesterol absorption.In contrast, the ferulic acid portion of gamma oryzanol is easily absorbed into the body's tissues. Ferulic acid also has demonstrated antioxidant properties in vitro.

White to Off-White Solid

ChEBI: Gamma-Oryzanol (TN) is a triterpenoid.

Gamma oryzanol is found in the by-products of the rice industry, such as rice bran and rice bran oil. It exhibits a wide range of biological activities, including anticarcinogenic, anti-inflammatory, antihyperlipidemic, and neuroprotective properties, which are primarily due to its high antioxidant capacity.

A poison by skin contact. Moderately toxic by intravenous route. Low toxicity by ingestion. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.

Gamma oryzanol Basic Attributes

Molecular Weight：

602.89

EC Number：

600-960-6

Color/Form：

White to Light yellow

HScode：

3822.19.0080

Characteristics

Density：

0.9751 (rough estimate)

Melting Point：

135-137°C

Boiling Point：

571.92°C (rough estimate)

Refractive Index：

1.4760 (estimate)

Water Solubility：

Practically insoluble in water

Toxicity：

LD50 oral in rat: > 25gm/kg

Odor：

little or no odor

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

Packing level：

Hazard category：

6.1

wgk germany：

WGK 3

RTECS Number：

RN0050000

RIDADR：

UN 2811 6.1/PG II

Gamma oryzanol Use and Manufacturing

Gamma Oryzanol is a mixture of 6 substances derived from rice bran oil, including sterols and ferulic acid, called Cycloartanyl Ferulate or Triterpene alcohol ferulate. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol. gamma oryzanol is widely used as a food additive, pharmaceutical material. In cosmetic area, the application to creams and sunscreens exploiting its skin age resistor function and ultraviolet absorbing effect.

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