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Quinine hydrochloride

Quinine hydrochloride structure

CAS No:
130-89-2
Formula:
C20H25ClN2O2
Chemical Name:
Quinine hydrochloride
Synonyms:
QUININE HYDROCHLORIDE;QUININE MONOHYDROCHLORIDE;6’-methoxy-,monohydrochloride,(8.alpha.,9R)-Cinchonan-9-ol;6’-methoxy-,monohydrochloride,(8-alpha,9r)-cinchonan-9-o;6’-methoxy-,monohydrochloride,(8alpha,9theta)-cinchonan-9-o;chinimetten;quininechloride;quininemuriate
Categories:
Specialty Chemicals

Description

Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.

Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.

Quinine hydrochloride Basic Attributes

Molecular Weight：

360.88

EC Number：

205-001-1

TSCA：

TSCA listed

Color/Form：

White

HScode：

29392000

Characteristics

Density：

1.1206 (rough estimate)

Melting Point：

158-160 C

Refractive Index：

1.5400 (estimate)

Water Solubility：

549.7mg/L(25 ºC)

Toxicity：

cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

hazard class code：

safety instructions：

26-36-24/25

Storage features：

Store at -20°C

Hazard Statements：

36/37/38

RIDADR：

1544

Quinine hydrochloride Use and Manufacturing

Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

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